基本信息:
- 专利标题: PHARMACEUTICAL PROCESS AND INTERMEDIATES
- 申请号:PCT/EP2019/085568 申请日:2019-12-17
- 公开(公告)号:WO2020127208A3 公开(公告)日:2020-06-25
- 发明人: GRAHAM, Mark, Andrew , JACKSON, Lucinda, Victoria , NOONAN, Gary, Michael , INGLESBY, Phillip, Anthony , DAVE, David, Pranay , COOPER, Katie, Grace
- 申请人: ASTRAZENECA AB
- 申请人地址: 151 85 Södertälje SE
- 专利权人: ASTRAZENECA AB
- 当前专利权人: ASTRAZENECA AB
- 当前专利权人地址: 151 85 Södertälje SE
- 代理机构: WALTON, Laura, Helen
- 优先权: US62/859,259 20190610; US62/780,993 20181218
- 主分类号: C12P17/16
- IPC分类号: C12P17/16 ; C07D413/04 ; C07D413/14 ; A61K31/5377 ; C07D471/04 ; C07D239/24 ; C07C255/58 ; C07D209/88 ; C07F5/02 ; C12P11/00
摘要:
The present disclosure concerns the large-scale manufacture of pharmaceutical compounds, and novel intermediates for use in the manufacture. International Patent Application WO2011154737 discloses morpholine pyrimidines useful for treating cancer, processes for their preparation and pharmaceutical compositions thereof. In particular, WO2011154737 discloses, as experimental Example 2.02 on page 60, the compound 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[l-((R)-S-methylsulfonimidoyl)cyclopropyl]pyrimidin-2-yl}-lH- pyrrolo[2,3 -b]pyridine (hereafter referred to as the compound of Formula (I)). The structure of the compound of Formula (I) is shown below. A synthetic route to the compound of Formula (I) is described at pages 51 to 57, 66 and 67 of WO2011154737, and is summarised below in Scheme 1.
公开/授权文献:
- WO2020127208A2 PHARMACEUTICAL PROCESS AND INTERMEDIATES 公开/授权日:2020-06-25
IPC结构图谱:
C | 化学;冶金 |
--C12 | 生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程 |
----C12P | 发酵或使用酶的方法合成目标化合物或组合物或从外消旋混合物中分离旋光异构体 |
------C12P17/00 | 仅有O,N,S,Se或Te作为杂环原子的杂环碳化合物的制备 |
--------C12P17/16 | .含有两个或更多的杂环 |