基本信息:
- 专利标题： DIARYLHYDANTOIN COMPOUNDS AND METHODS OF USE THEREOF
- 申请号：PCT/US2019/063734 申请日：2019-11-27
- 公开(公告)号：WO2020113088A1 公开(公告)日：2020-06-04
- 发明人： PETTIGREW, Jeremy D. , CHAKRAVARTY, Sarvajit , PHAM, Son Minh , CHEN, Jiyun , KANKANALA, Jayakanth , NAYAK, Anjan Kumar , BARDE, Anup , PUJALA, Brahmam
- 申请人： NUVATION BIO INC. , PETTIGREW, Jeremy D.
- 申请人地址： c/o Sheppard Mullin Richter & Hampton LLP Four Embarcadero Center, Suite 1700 San Francisco, California 94111 US
- 专利权人： NUVATION BIO INC.,PETTIGREW, Jeremy D.
- 当前专利权人： NUVATION BIO INC.,PETTIGREW, Jeremy D.
- 当前专利权人地址： c/o Sheppard Mullin Richter & Hampton LLP Four Embarcadero Center, Suite 1700 San Francisco, California 94111 US
- 代理机构： TANNER, Lorna L. et al.
- 优先权： US62/774,058 20181130
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; A61K31/4427 ; C07D401/00 ; C07D401/14
摘要：
The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation. The present disclosure provides compounds having hormone receptor antagonist activity. These compounds can be useful in treating cancer, in particular those cancers which can be potentiated by AR and/or GR antagonism.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/44 | ....非稠合的吡啶；其氢化的衍生物 |
| ----------------A61K31/4427 | .....含另外的杂环的 |
| ------------------A61K31/4439 | ......含有氮作为环杂原子的五元环的，例如奥美拉唑 |