发明申请
WO2019222560A1 METHODS AND REAGENTS FOR RESOLVING NUCLEIC ACID MIXTURES AND MIXED CELL POPULATIONS AND ASSOCIATED APPLICATIONS
审中-公开
基本信息:
- 专利标题： METHODS AND REAGENTS FOR RESOLVING NUCLEIC ACID MIXTURES AND MIXED CELL POPULATIONS AND ASSOCIATED APPLICATIONS
- 申请号：PCT/US2019/032755 申请日：2019-05-16
- 公开(公告)号：WO2019222560A1 公开(公告)日：2019-11-21
- 发明人： SALK, Jesse, J. , VALENTINE, Charles, Clinton, III , DANAHER, Patrick , LO, Fang, Yin
- 申请人： TWINSTRAND BIOSCIENCES, INC.
- 申请人地址： 3131 Elliott Avenue, Suite 750 Seattle, WA 98121 US
- 专利权人： TWINSTRAND BIOSCIENCES, INC.
- 当前专利权人： TWINSTRAND BIOSCIENCES, INC.
- 当前专利权人地址： 3131 Elliott Avenue, Suite 750 Seattle, WA 98121 US
- 代理机构： VRABLIK, Tracy, L. et al.
- 优先权： US62/672,573 20180516; US62/811,517 20190227
- 主分类号： C12N15/10
- IPC分类号： C12N15/10 ; C04B20/04 ; G06F19/22
摘要：
Methods and associated reagents for assessing and resolving nucleic acid mixtures and/or mixed cell populations are disclosed herein. Some embodiments of the technology are directed to utilizing Duplex Sequencing for assessing and resolving nucleic acid mixtures (e.g., multichimeric mixtures, mixtures of nucleic acids from more than one source, etc.) in a sample and associated applications. Other embodiments are directed to detecting and quantifying a donor source of nucleic acid from a mixture.