基本信息:
- 专利标题： INTEGRIN TARGETING LIGANDS AND USES THEREOF
- 申请号：PCT/US2019/029676 申请日：2019-04-29
- 公开(公告)号：WO2019210308A1 公开(公告)日：2019-10-31
- 发明人： LI, Zhen , CARLSON, Jeffrey , NICHOLAS, Anthony , LI, Xiaokai , SHU, Dongxu , FOWLER-WATTERS, Matthew
- 申请人： ARROWHEAD PHARMACEUTICALS, INC.
- 申请人地址： 225 South Lake Avenue, Suite 1050 Pasadena, CA 91101 US
- 专利权人： ARROWHEAD PHARMACEUTICALS, INC.
- 当前专利权人： ARROWHEAD PHARMACEUTICALS, INC.
- 当前专利权人地址： 225 South Lake Avenue, Suite 1050 Pasadena, CA 91101 US
- 代理机构： VANDERVELDE, Paul
- 优先权： US62/663,763 20180427
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; C07K14/705
摘要：
Compounds having affinity for integrins, the synthesis of these compounds, and the use of these compounds as ligands to facilitate the delivery of cargo molecules to cells expressing integrins are described. The described integrin targeting ligands have serum stability and affinity for ανβ3 integrin and/or ανβ5 integrin, and are suitable for conjugation to cargo molecules, such as such as oligonucleotide-based therapeutic agents (e.g., RNAi agents), to facilitate delivery of the cargo molecules to cells and tissues, such as tumor cells, that express integrin ανβ3, integrin ανβ5, or both integrin ανβ3 and integrin ανβ5. Compositions that include integrin targeting ligands and methods of use are also described.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K38/00 | 含肽的医药配制品 |
| --------A61K38/04 | .在完全确定的序列中最多有20个氨基酸的肽；其衍生物 |
| ----------A61K38/17 | ..来源于动物；来源于人类 |