基本信息:
- 专利标题： PLADIENOLIDE COMPOUNDS AND THEIR USE
- 申请号：PCT/US2019/026313 申请日：2019-04-08
- 公开(公告)号：WO2019199667A3 公开(公告)日：2019-10-17
- 发明人： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , MARCAURELLE, Lisa A. , NEVALAINEN, Marta , HAO, Ming-Hong , O'SHEA, Morgan Welzel , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , LUO, Touping , GEARHART, Nicholas C. , LOWE, Jason T. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONOBE, Regina Mikie , MIYANO, Masayuki , MURAI, Norio , COOK, Andrew , ELLERY, Shelby , ENDO, Atsushi , PALACINO, James , REYNOLDS, Dominic
- 申请人： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , MARCAURELLE, Lisa A. , NEVALAINEN, Marta , HAO, Ming-Hong , O'SHEA, Morgan Welzel , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , LUO, Touping , GEARHART, Nicholas C. , LOWE, Jason T. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONOBE, Regina Mikie , MIYANO, Masayuki , MURAI, Norio , COOK, Andrew , ELLERY, Shelby , ENDO, Atsushi , PALACINO, James , REYNOLDS, Dominic
- 申请人地址： 34 Robbins Road Lexington, Massachusetts 02421 US
- 专利权人： KEANEY, Gregg F.,WANG, John,GERARD, Baudouin,ARAI, Kenzo,LIU, Xiang,ZHENG, Guo Zhu,KIRA, Kazunobu,MARCAURELLE, Lisa A.,NEVALAINEN, Marta,HAO, Ming-Hong,O'SHEA, Morgan Welzel,TIVITMAHAISOON, Parcharee,PRAJAPATI, Sudeep,LUO, Touping,GEARHART, Nicholas C.,LOWE, Jason T.,KOTAKE, Yoshihiko,NAGAO, Satoshi,KANADA SONOBE, Regina Mikie,MIYANO, Masayuki,MURAI, Norio,COOK, Andrew,ELLERY, Shelby,ENDO, Atsushi,PALACINO, James,REYNOLDS, Dominic
- 当前专利权人： KEANEY, Gregg F.,WANG, John,GERARD, Baudouin,ARAI, Kenzo,LIU, Xiang,ZHENG, Guo Zhu,KIRA, Kazunobu,MARCAURELLE, Lisa A.,NEVALAINEN, Marta,HAO, Ming-Hong,O'SHEA, Morgan Welzel,TIVITMAHAISOON, Parcharee,PRAJAPATI, Sudeep,LUO, Touping,GEARHART, Nicholas C.,LOWE, Jason T.,KOTAKE, Yoshihiko,NAGAO, Satoshi,KANADA SONOBE, Regina Mikie,MIYANO, Masayuki,MURAI, Norio,COOK, Andrew,ELLERY, Shelby,ENDO, Atsushi,PALACINO, James,REYNOLDS, Dominic
- 当前专利权人地址： 34 Robbins Road Lexington, Massachusetts 02421 US
- 代理机构： MACALPINE, Jill K.
- 优先权： US62/655,021 20180409; US62/679,653 20180601; US62/814,838 20190306; US62/814,843 20190306
- 主分类号： C07D313/00
- IPC分类号： C07D313/00 ; C07D407/12 ; C07D407/14 ; A61K31/497 ; A61K31/4427 ; A61K31/365 ; A61P35/00
摘要：
The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.
公开/授权文献:
- WO2019199667A2 CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE 公开/授权日：2019-10-17
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D313/00 | 杂环化合物，含大于六元的环，有1个氧原子作为仅有的杂环原子 |