基本信息:
- 专利标题： TISSUE RESIDENT MEMORY CELL PROFILES, AND USES THEREOF
- 申请号：PCT/US2019/023767 申请日：2019-03-22
- 公开(公告)号：WO2019183610A1 公开(公告)日：2019-09-26
- 发明人： VIJAYANAND, Pandurangan , OTTENSMEIER, Christian , CLARKE, James , SANCHEZ-ELSNER, Tilman , ESCHWEILER, Simon , AY, Ferhat
- 申请人： LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , UNIVERSITY OF SOUTHAMPTON , VIJAYANAND, Pandurangan , OTTENSMEIER, Christian , CLARKE, James , SANCHEZ-ELSNER, Tilman , ESCHWEILER, Simon , AY, Ferhat
- 申请人地址： 9420 Athena Circle La Jolla, California 92037 US
- 专利权人： LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY,UNIVERSITY OF SOUTHAMPTON,VIJAYANAND, Pandurangan,OTTENSMEIER, Christian,CLARKE, James,SANCHEZ-ELSNER, Tilman,ESCHWEILER, Simon,AY, Ferhat
- 当前专利权人： LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY,UNIVERSITY OF SOUTHAMPTON,VIJAYANAND, Pandurangan,OTTENSMEIER, Christian,CLARKE, James,SANCHEZ-ELSNER, Tilman,ESCHWEILER, Simon,AY, Ferhat
- 当前专利权人地址： 9420 Athena Circle La Jolla, California 92037 US
- 代理机构： KONSKI, Antoinette F. et al.
- 优先权： US62/647,588 20180323; US62/770,412 20181121
- 主分类号： C12N5/0783
- IPC分类号： C12N5/0783 ; A61K35/17 ; C12Q1/6886 ; A61K39/395 ; A61P35/00 ; C07K16/30
摘要：
This disclosure provides methods of treating cancer or eliciting an anti-tumor response in a subject by administering an effective amount of a population of T-cells that exhibits higher or lower than baseline expression of one or more genes. In other aspects, methods are provided to diagnose cancer and determine prognosis of cancer patients. Also provided are methods to identify the antigens or antigen receptors associated with the isolated and/or purified cell populations that elicit a more positive prognosis.
公开/授权文献:
- WO2019183610A9 TISSUE RESIDENT MEMORY CELL PROFILES, AND USES THEREOF 公开/授权日：2019-09-26