发明申请
WO2019136160A1 WATER- AND FAT-SOLUBLE MICRONUTIENT-STABILISED PARTICLES WITH AN ENTERIC POLYMER BARRIER
审中-公开
基本信息:
- 专利标题： WATER- AND FAT-SOLUBLE MICRONUTIENT-STABILISED PARTICLES WITH AN ENTERIC POLYMER BARRIER
- 申请号：PCT/US2019/012197 申请日：2019-01-03
- 公开(公告)号：WO2019136160A1 公开(公告)日：2019-07-11
- 发明人： ANSELMO, Aaron , XU, Xian , TANG, Wen , LANGER, Robert S. , JAKLENEC, Ana
- 申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 申请人地址： 77 Massachusetts Avenue Cambridge, Massachusetts 02139 US
- 专利权人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 当前专利权人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 当前专利权人地址： 77 Massachusetts Avenue Cambridge, Massachusetts 02139 US
- 代理机构： PABST, Patrea L. et al.
- 优先权： US62/613,485 20180104
- 主分类号： A23L33/15
- IPC分类号： A23L33/15 ; A23K20/174 ; A23K20/20 ; A23L33/16 ; A61K9/50 ; A61K31/295 ; A61K31/375 ; A61K31/519 ; A61K31/593 ; A61K31/714 ; A61K33/18 ; A61K33/26 ; A61K33/30 ; A23L27/00
摘要：
Particulate formulations containing one or more micronutrients such as iron supplements such as ferrous sulfate, fat or oil soluble vitamins such as vitamin A, D, and E, water soluble vitamins such as B vitamin family, and other micronutrients have been developed. These formulations resist oxidation and loss of bioactivity during processing, storage and cooking. The particles include one or more enteric polymers such as pH-sensitive polymers. To prevent oxidation, the iron supplements are encapsulated by a polymer such as hyaluronic acid ("HA"), preferably in a ratio of iron:HA of between 1:4 and 1:10), or mixed with a compound such as vitamin C. The resulting mixture is then dispersed in a solution of a enteric polymer, and manufactured using techniques such as spray drying or spinning disc atomization into particles into particles.