基本信息:
- 专利标题： COMPOSITIONS AND METHODS FOR TREATING AUTOIMMUNE DISEASE
- 申请号：PCT/US2018/067832 申请日：2018-12-28
- 公开(公告)号：WO2019133793A1 公开(公告)日：2019-07-04
- 发明人： LEES, Jason R.
- 申请人： THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
- 申请人地址： 6720-A Rockledge Drive Suite 100 Bethesda, Maryland 20817 US
- 专利权人： THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
- 当前专利权人： THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
- 当前专利权人地址： 6720-A Rockledge Drive Suite 100 Bethesda, Maryland 20817 US
- 代理机构： BRINCKERHOFF, Courtenay et al.
- 优先权： US62/612,096 20171229
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; C07K16/18 ; C12N5/0783
摘要：
Provided herein are compositions comprising engineered CD8+ T cells that express a heterologous T cell receptor (TCR) having specificity for an autoantigen bound to a Major Histocompatibility Complex (MHC) Class II. Also provided are methods for the treatment of an autoimmune disease comprising administering the engineered CD8+ T cells. Also provided are methods for generating engineered CD8+ T cells that express a heterologous MHC Class II TCR, including methods of isolating autoantigen-MHC class II specific TCR for use in engineering CD8+ T cells for treatment.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |