基本信息:
- 专利标题： ARYL AND HETEROARYL SUBSTITUTED INDOLE COMPOUNDS
- 申请号：PCT/US2018/066366 申请日：2018-12-19
- 公开(公告)号：WO2019126253A8 公开(公告)日：2019-06-27
- 发明人： DYCKMAN, Alaric J. , MUSSARI, Christopher P. , HAQUE, Tasir Shamsul , WHITELEY, Brian K. , POSY, Shoshana L. , KUMAR, Sreekantha Ratna , PASUNOORI, Laxman , HEGDE, Subramanya , RAMACHANDRA REDDY, Anupama Kandhi , ANUMULA, Rushith Kumar
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址： Route 206 and Province Line Road Princeton, New Jersey 08543 US
- 专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人地址： Route 206 and Province Line Road Princeton, New Jersey 08543 US
- 代理机构： GREENBLATT, Gary D. et al.
- 优先权： US62/607,998 20171220
- 主分类号： C07D209/12
- IPC分类号： C07D209/12 ; C07D401/04 ; C07D401/10 ; C07D401/12 ; C07D401/14 ; C07D403/14 ; C07D413/14 ; C07D417/14 ; C07D451/02 ; C07D453/02 ; C07D471/04 ; C07D487/04 ; C07D513/04 ; A61P37/00 ; A61K31/4353
摘要：
Disclosed are compounds of Formula (I) or salts thereof, wherein A, G, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
公开/授权文献:
- WO2019126253A1 ARYL AND HETEROARYL SUBSTITUTED INDOLE COMPOUNDS 公开/授权日：2019-06-27
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D209/00 | 杂环化合物，含五元环、与其他环稠合、带1个氮原子作为惟一的杂环原子 |
| --------C07D209/02 | .与一个碳环稠合 |
| ----------C07D209/04 | ..吲哚；氢化吲哚 |
| ------------C07D209/10 | ...有被杂原子取代的烃基，直接连在杂环的碳原子上 |
| --------------C07D209/12 | ....被氧原子取代的基 |