基本信息:
- 专利标题： IMMUNOTOXINS FOR TREATING CANCER
- 申请号：PCT/IL2018/051245 申请日：2018-11-20
- 公开(公告)号：WO2019102456A1 公开(公告)日：2019-05-31
- 发明人： JONJIC, Stipan , SIMIC, Hrvoje , MANDELBOIM, Ofer
- 申请人： UNIVERSITY OF RIJEKA FACULTY OF MEDICINE , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
- 申请人地址： Brace Branchetta 20 51000 Rijeka HR
- 专利权人： UNIVERSITY OF RIJEKA FACULTY OF MEDICINE,YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
- 当前专利权人： UNIVERSITY OF RIJEKA FACULTY OF MEDICINE,YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
- 当前专利权人地址： Brace Branchetta 20 51000 Rijeka HR
- 代理机构： HORNIK, Vered et al.
- 优先权： US62/590,656 20171127
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K47/68 ; G01N33/53
摘要：
The present invention provides antibody molecules that recognize poliovirus receptor (PVR) and immunotoxins thereof comprising a toxin for treating cancer. The present invention further provides pharmaceutical compositions comprising the immunotoxins and methods for their use in treating cancer such as glioblastoma.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K16/00 | 免疫球蛋白，例如，单克隆或多克隆抗体 |
| --------C07K16/18 | .来自动物或人的抵抗物质 |
| ----------C07K16/28 | ..抗受体，细胞表面抗原或细胞表面决定因子 |