基本信息:
- 专利标题： NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS
- 申请号：PCT/EP2018/080746 申请日：2018-11-09
- 公开(公告)号：WO2019092172A1 公开(公告)日：2019-05-16
- 发明人： COOPER, Matthew , MILLER, David , MACLEOD, Angus , THOM, Stephen , ST-GALLAY, Stephen , SHANNON, Jonathan
- 申请人： INFLAZOME LIMITED
- 申请人地址： 88 Harcourt Street Dublin 2 IE
- 专利权人： INFLAZOME LIMITED
- 当前专利权人： INFLAZOME LIMITED
- 当前专利权人地址： 88 Harcourt Street Dublin 2 IE
- 代理机构： JOHNSON, Stephen et al.
- 优先权： GB1718563.8 20171109; GB1721726.6 20171222; GB1721727.4 20171222; GB1721729.0 20171222; GB1721731.6 20171222; GB1721732.4 20171222; GB1803391.0 20180302; GB1810983.5 20180704; GB1813285.2 20180815
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; C07D405/14 ; A61K31/415 ; A61K31/4155 ; A61K31/4433 ; A61K31/4439 ; A61K31/5377 ; C07D231/18 ; C07D401/12 ; C07D403/06 ; C07D405/04 ; C07D413/06
摘要：
The present invention relates to sulfonylureas and sulfonylthioureas comprising a 5-membered nitrogen-containing heteroaryl ring attached to the sulfonyl group, wherein the heteroaryl ring is substituted with at least one monovalent group comprising a non- aromatic cyclic group, and wherein the group attached to the terminal nitrogen atom of the urea group is a 6-membered cyclic group substituted at the2- and4-positions. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLF^inhibition.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D401/00 | 杂环化合物，含有两个或更多个杂环，以氮原子作为仅有的杂环原子，至少有1个环是仅含有1个氮原子的六元环 |
| --------C07D401/14 | .含有3个或更多个杂环 |