发明申请
WO2019077125A1 METHODS FOR DETERMINING WHETHER A SUBJECT HAS OR IS AT RISK OF HAVING A NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) OR ONE OF ITS COMPLICATIONS
审中-公开
基本信息:
- 专利标题： METHODS FOR DETERMINING WHETHER A SUBJECT HAS OR IS AT RISK OF HAVING A NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) OR ONE OF ITS COMPLICATIONS
- 申请号：PCT/EP2018/078750 申请日：2018-10-19
- 公开(公告)号：WO2019077125A1 公开(公告)日：2019-04-25
- 发明人： BURCELIN, Rémy , FEDERICI, Massimo , HOYLES, Lesley , DUMAS, Marc-Emmanuel , BARTON, Richard Hadlow , FERNANDEZ-REAL, José Manuel
- 申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ PAUL SABATIER TOULOUSE III , UNIVERSITÀ DEGLI STUDI DI ROMA "TOR VERGATA" , IMPERIAL COLLEGE LONDON , HOSPITAL UNIVERSITARI DE GIRONA DOCTOR JOSEP TRUETA
- 申请人地址： 101, rue de Tolbiac 75013 Paris FR
- 专利权人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),UNIVERSITÉ PAUL SABATIER TOULOUSE III,UNIVERSITÀ DEGLI STUDI DI ROMA "TOR VERGATA",IMPERIAL COLLEGE LONDON,HOSPITAL UNIVERSITARI DE GIRONA DOCTOR JOSEP TRUETA
- 当前专利权人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),UNIVERSITÉ PAUL SABATIER TOULOUSE III,UNIVERSITÀ DEGLI STUDI DI ROMA "TOR VERGATA",IMPERIAL COLLEGE LONDON,HOSPITAL UNIVERSITARI DE GIRONA DOCTOR JOSEP TRUETA
- 当前专利权人地址： 101, rue de Tolbiac 75013 Paris FR
- 代理机构： INSERM TRANSFERT
- 优先权： EP17306449.4 20171020
- 主分类号： G01N33/92
- IPC分类号： G01N33/92
摘要：
Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition often observed in obese patients. Here, the inventors showed that plasma levels of phenylacetic acid (PAA, a metabolite resulting from microbial proteolysis associated with steatosis) correlates with steatosis and induces lipid accumulation and BCAA utilization in primary human hepatocytes and to some extent in mice. Accordingly, this metabolite could be used as a biomarker of NAFLD for stratifying the patients according to their risk.