发明申请
WO2019071195A1 A METHOD OF SEQUENCE TYPING WITH IN SILICO APTAMERS FROM A NEXT GENERATION SEQUENCING PLATFORM
审中-公开
基本信息:
- 专利标题： A METHOD OF SEQUENCE TYPING WITH IN SILICO APTAMERS FROM A NEXT GENERATION SEQUENCING PLATFORM
- 申请号：PCT/US2018/054707 申请日：2018-10-05
- 公开(公告)号：WO2019071195A1 公开(公告)日：2019-04-11
- 发明人： ESPITIA, Hector , CHANDE, Aroon T. , JORDAN, Irving King , RISHISHWAR, Lavanya
- 申请人： AAGEY HOLDING, LLC
- 申请人地址： 2 Ravinia Drive Suite 1200 Atlanta, Georgia 30346 US
- 专利权人： AAGEY HOLDING, LLC
- 当前专利权人： AAGEY HOLDING, LLC
- 当前专利权人地址： 2 Ravinia Drive Suite 1200 Atlanta, Georgia 30346 US
- 代理机构： WATSON, Jeffrey
- 优先权： US15/726,005 20171005
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C12N15/113 ; C12Q1/02 ; G06G7/48
摘要：
A method of sequence typing with in silico aptamers from a next generation sequencing (NGS) platform includes a database indexing phase and a sequence variant detection phase. The database indexing phase includes breaking down each of a plurality of input sequences into k-mers, where the k-mers are subsequences of a length k, where the length k is a user defined positive integer, and constructing an enhanced suffix array (ESA) index out of each k-mer from the plurality of input sequences. The sequence variant detection phase includes using an input NGS read file with a plurality of reads. Wherein, the sequence variant detection phase includes using the ESA index constructed out of each k-mer from the plurality of input sequences from the database indexing phase for sequence variant detection.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07H | 糖类；及其衍生物；核苷；核苷酸；核酸 |
| ------C07H21/00 | 含有两个或多个单核苷酸单元的化合物，具有以核苷基的糖化物基团连接的单独的磷酸酯基或多磷酸酯基，例如核酸 |
| --------C07H21/02 | .以核糖基作为糖化物基团 |