基本信息:
- 专利标题： VASOPRESSIN RECEPTOR ANTAGONISTS AND PRODUCTS AND METHODS RELATED THERETO
- 申请号：PCT/US2018/049607 申请日：2018-09-05
- 公开(公告)号：WO2019050988A1 公开(公告)日：2019-03-14
- 发明人： JONES, Robert, M. , URBANO, Mariangela , BRANDT, Gary , CHAMBERS, Mark , HARDICK, David , TIERNEY, Jason , KNIGHT, Chris , LOCK, Chris
- 申请人： BLACKTHORN THERAPEUTICS, INC. , JONES, Robert, M. , URBANO, Mariangela , BRANDT, Gary
- 申请人地址： 780 Brannan Street San Francisco, California 94103 US
- 专利权人： BLACKTHORN THERAPEUTICS, INC.,JONES, Robert, M.,URBANO, Mariangela,BRANDT, Gary
- 当前专利权人： BLACKTHORN THERAPEUTICS, INC.,JONES, Robert, M.,URBANO, Mariangela,BRANDT, Gary
- 当前专利权人地址： 780 Brannan Street San Francisco, California 94103 US
- 代理机构： COOPER, Michael, P. et al.
- 优先权： US62/554,452 20170905
- 主分类号： C07D487/10
- IPC分类号： C07D487/10 ; C07D519/00 ; A61P25/00 ; A61P9/00 ; A61K31/538 ; A61K31/4439 ; A61K31/553 ; A61K31/5513 ; A61K31/5415
摘要：
Compounds are provided that antagonize vasopressin receptors, particularly the V1a receptor products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof: (I) wherein Q 1 , Q 2 , Q 3 , R 2a , R 2b , R 3 and X are as defined herein.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D487/00 | 在稠环系中含有氮原子作为仅有的杂环原子的杂环化合物，不包含在C07D451/00至C07D477/00组中 |
| --------C07D487/02 | .在稠合系中含有两个杂环 |
| ----------C07D487/10 | ..螺稠合系 |