基本信息:
- 专利标题： IMPROVED IMMUNOTHERAPY
- 申请号：PCT/SE2018/050893 申请日：2018-09-06
- 公开(公告)号：WO2019050458A1 公开(公告)日：2019-03-14
- 发明人： LUDVIGSSON, Johnny , CASAS, Rosaura , HANNELIUS, Ulf , LINDQVIST, Anton , ESSEN-MÖLLLER, Anders
- 申请人： DIAMYD MEDICAL AB
- 申请人地址： Kungsgatan 29 111 56 Stockholm SE
- 专利权人： DIAMYD MEDICAL AB
- 当前专利权人： DIAMYD MEDICAL AB
- 当前专利权人地址： Kungsgatan 29 111 56 Stockholm SE
- 代理机构： ZACCO SWEDEN AB
- 优先权： SE1751091-8 20170908; SE1850017-3 20180107
- 主分类号： G01N33/564
- IPC分类号： G01N33/564 ; A61K31/592 ; A61K31/593 ; A61K39/00 ; A61P3/10 ; A61K38/51 ; G01N33/15 ; G01N33/569
摘要：
The invention relates to a method for assessing the efficacy of an immunotherapy comprising administration of GAD to a patient, comprising the following steps: measuring at least one of GADA IgG subclass distribution; GADA levels; distribution of cytokines secreted from lymphocytes; and lymphocyte proliferation in presence of GAD or CD3/CD28 beads; in a first blood, plasma or serum sample obtained from said patient at a first point in time and in a second blood, plasma or serum sample obtained from said patient at a later point in time; and comparing the so obtained measurements. The invention also relates to novel administration regimens of GAD in treatment or prevention of type 1 diabetes, that may include administration by injection into a lymph node, oral administration of vitamin D and/or an assessment of efficacy according to the above methodology followed by an adjustment of dosage and/or administration route based on said assessment.
IPC结构图谱:
| G | 物理 |
| --G01 | 测量；测试 |
| ----G01N | 借助于测定材料的化学或物理性质来测试或分析材料 |
| ------G01N33/00 | 利用不包括在G01N1/00至G01N31/00组中的特殊方法来研究或分析材料 |
| --------G01N33/48 | .生物物质，例如血、尿（G01N33/02至G01N33/14，G01N33/26，G01N33/44，G01N33/46优先；种子发芽能力测定入A01C1/02）；血球计数器 |
| ----------G01N33/483 | ..生物物质的物理分析 |
| ------------G01N33/53 | ...免疫测定法；生物特有的结合方法的测定；相应的生物物质 |
| --------------G01N33/564 | ....用于先存在抗原抗体复合物或者自动免疫疾病的 |