发明申请
WO2019036534A1 INDAZOLE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION
审中-公开
基本信息:
- 专利标题： INDAZOLE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION
- 申请号：PCT/US2018/046801 申请日：2018-08-16
- 公开(公告)号：WO2019036534A1 公开(公告)日：2019-02-21
- 发明人： CONN, P. Jeffrey , LINDSLEY, Craig W. , FELTS, Andrew , NISWENDER, Colleen M. , CAPSTICK, Rory A. , SPEARING, Paul K. , BOLLINGER, Sean
- 申请人： VANDERBILT UNIVERSITY
- 申请人地址： 305 Kirkland Hall Nashville, Tennessee 37240 US
- 专利权人： VANDERBILT UNIVERSITY
- 当前专利权人： VANDERBILT UNIVERSITY
- 当前专利权人地址： 305 Kirkland Hall Nashville, Tennessee 37240 US
- 代理机构： MYERS JR., Richard S et al.
- 优先权： US62/546,290 20170816
- 主分类号： C07D407/14
- IPC分类号： C07D407/14 ; C07D409/14 ; C07D471/04 ; A61P25/00 ; A61K31/4523 ; A61K31/437 ; A61K31/416
摘要：
Indazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D407/00 | 杂环化合物，含两个或更多个杂环，至少有1个环有氧原子作为仅有的杂环原子，C07D405/00组不包含的 |
| --------C07D407/14 | .含3个或更多个杂环 |