基本信息:
- 专利标题： NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS
- 申请号：PCT/EP2018/072111 申请日：2018-08-15
- 公开(公告)号：WO2019034686A1 公开(公告)日：2019-02-21
- 发明人： COOPER, Matthew , MILLER, David , MACLEOD, Angus , VAN WILTENBURG, Jimmy , THOM, Stephen , ST-GALLAY, Stephen , SHANNON, Jonathan , ALANINE, Thomas , ONIONS, Stuart , STRUTT, Ian
- 申请人： INFLAZOME LIMITED
- 申请人地址： 88 Harcourt Street Dublin 2 IE
- 专利权人： INFLAZOME LIMITED
- 当前专利权人： INFLAZOME LIMITED
- 当前专利权人地址： 88 Harcourt Street Dublin 2 IE
- 代理机构： ELEND, Almut et al.
- 优先权： GB1713082.4 20170815; GB1718563.8 20171109; GB1721726.6 20171222; GB1810983.5 20180704
- 主分类号： C07D403/12
- IPC分类号： C07D403/12 ; C07D401/14 ; A61K31/64 ; C07D231/18 ; C07D401/12 ; C07D405/04 ; C07D405/12 ; C07D407/12 ; C07D407/14 ; C07D413/12 ; C07D417/12 ; C07D471/08 ; C07D487/04 ; C07D491/048 ; C07D213/52
摘要：
The present invention relates to compounds of formula (I): Formula (I) wherein Q is selected from O or S; R 1 is a saturated or unsaturated, optionally substituted hydrocarbyl group optionally including one or more heteroatoms N, O or S; and R 2 is a cyclic group substituted at the α-position with a monovalent heterocyclic 10 group or a monovalent aromatic group, wherein a ring atom of the heterocyclic or aromatic group is directly attached to the α ring atom of the cyclic group, wherein the heterocyclic or aromatic group may optionally be substituted, and wherein the cyclic group may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP 3 .
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D403/00 | 杂环化合物，含有两个或更多的杂环，以氮原子作为仅有的杂环原子，C07D401/00组不包含的 |
| --------C07D403/02 | .含两个杂环 |
| ----------C07D403/12 | ..被含有杂原子的链作为键链连接的 |