发明申请
WO2019032524A1 SYNTHESIS AND CHARACTERIZATION OF WELL DEFINED POLY(PROPYLENE FUMARATE) AND POLY(ETHYLENE GLYCOL) BLOCK COPOLYMERS
审中-公开
基本信息:
- 专利标题： SYNTHESIS AND CHARACTERIZATION OF WELL DEFINED POLY(PROPYLENE FUMARATE) AND POLY(ETHYLENE GLYCOL) BLOCK COPOLYMERS
- 申请号：PCT/US2018/045520 申请日：2018-08-07
- 公开(公告)号：WO2019032524A1 公开(公告)日：2019-02-14
- 发明人： BECKER, Matthew , WILSON, James A. , DILLA, Rodger A.
- 申请人： THE UNIVERSITY OF AKRON , BECKER, Matthew , WILSON, James A. , DILLA, Rodger A.
- 申请人地址： 302 E. Buchtel Common Akron, Ohio 44325 US
- 专利权人： THE UNIVERSITY OF AKRON,BECKER, Matthew,WILSON, James A.,DILLA, Rodger A.
- 当前专利权人： THE UNIVERSITY OF AKRON,BECKER, Matthew,WILSON, James A.,DILLA, Rodger A.
- 当前专利权人地址： 302 E. Buchtel Common Akron, Ohio 44325 US
- 代理机构： DIAZ, Robert et al.
- 优先权： US62/541,889 20170807
- 主分类号： A61L27/52
- IPC分类号： A61L27/52 ; C08G63/08 ; C08J3/075
摘要：
In one or more embodiments, the present invention provides a low molecular weight, non-toxic, resorbable poly(ethylene glycol)(PEG) -block- poly(propylene fumarate) (PPF) diblock copolymers and poly(propylene fumarate) (PPF) -block- poly(ethylene glycol)(PEG) -block- poly(propylene fumarate) (PPF) triblock copolymers (and related methods for their making and use) that permits hydration for the formation of such things as hydrogels and has constrained and predictable material properties suitable for 3D printing and drug delivery applications. Using continuous digital light processing (cDLP) hydrogels the diblock and triblock copolymers can be photochemically printed from an aqueous solution into structures having a 10-fold increase in elongation at break compared to traditional diethyl fumarate (DEF) based printing. Furthermore, PPF-PEG-PPF triblock hydrogels have also been found in vitro to be biocompatible across a number of engineered MC3T3, NIH3T3, and primary Schwann cells.
公开/授权文献:
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61L | 材料或物体消毒的一般方法或装置；空气的灭菌、消毒或除臭；绷带、敷料、吸收垫或外科用品的化学方面；绷带、敷料、吸收垫或外科用品的材料 |
| ------A61L27/00 | 假体材料或假体被覆材料 |
| --------A61L27/02 | .无机材料 |
| ----------A61L27/52 | ..水凝胶或水胶体 |