发明申请
WO2019005685A1 CHEMICAL INHIBITION OF THE E3 LIGASE SUBUNIT FBX07 CONFERS NEUROPROTECTION AND ANTI-INFLAMMATORY ACTIVITY BY STABILIZING MITOCHONDRIA
审中-公开
基本信息:
- 专利标题： CHEMICAL INHIBITION OF THE E3 LIGASE SUBUNIT FBX07 CONFERS NEUROPROTECTION AND ANTI-INFLAMMATORY ACTIVITY BY STABILIZING MITOCHONDRIA
- 申请号：PCT/US2018/039327 申请日：2018-06-25
- 公开(公告)号：WO2019005685A1 公开(公告)日：2019-01-03
- 发明人： MALLAMPALLI, Rama, K. , CHEN, Beibei , CHU, Charleen, T. , LIU, Yuan
- 申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , MALLAMPALLI, Rama, K. , CHEN, Beibei , CHU, Charleen, T. , LIU, Yuan
- 申请人地址： 1st Floor Gardner Steel Conference Center 130 Thackeray Avenue Pittsburgh, PA 15260 US
- 专利权人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION,MALLAMPALLI, Rama, K.,CHEN, Beibei,CHU, Charleen, T.,LIU, Yuan
- 当前专利权人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION,MALLAMPALLI, Rama, K.,CHEN, Beibei,CHU, Charleen, T.,LIU, Yuan
- 当前专利权人地址： 1st Floor Gardner Steel Conference Center 130 Thackeray Avenue Pittsburgh, PA 15260 US
- 代理机构： RUPERT, Wayne
- 优先权： US62/527,492 20170630
- 主分类号： C07D405/12
- IPC分类号： C07D405/12 ; C07D239/90 ; C07D239/78 ; C07D239/88 ; C07D239/74 ; C07D239/72 ; A61K31/517 ; A61P25/28 ; A61P29/00 ; A61P9/00 ; A61P21/00 ; A61P43/00
摘要：
A method for treating a neurodegenerative disease or an inflammatory disorder in a subject, comprising administering to the subject in need thereof, a compound, or a pharmaceutically acceptable salt thereof, of formula II: wherein each of R 3 -R 7 is independently H, halogen, optionally-substituted alkyl, amino, alkoxy or hydroxy; R 8 is an optionally-substituted heterocycloalkyl; and a is 0 to 3.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D405/00 | 杂环化合物，含有1个或多个以氧原子作为仅有的杂环原子的环，且含有1个或多个以氮原子作为仅有的杂环原子的环 |
| --------C07D405/02 | .含有两个杂环 |
| ----------C07D405/12 | ..被含有杂原子的链作为键链连接的 |