发明申请
WO2019000237A1 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF M4 MUSCARINIC ACETYLCHOLINE RECEPTOR
审中-公开
基本信息:
- 专利标题： 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF M4 MUSCARINIC ACETYLCHOLINE RECEPTOR
- 申请号：PCT/CN2017/090385 申请日：2017-06-27
- 公开(公告)号：WO2019000237A1 公开(公告)日：2019-01-03
- 发明人： ACTON, John J., III , BAO, Jianming , DENG, Qiaolin , EGBERTSON, Melissa , FERGUSON, Ronald , GAO, Xiaolei , HARRISON, Scott T. , HENDERSON, Timothy J. , KNOWLES, Sandra L. , LO, Michael Man-Chu , MAZZOLA, Robert D., Jr , SELYUTIN, Oleg , ZHANG, Fengqi , NA, Meng , SUZUKI, Takao
- 申请人： MERCK SHARP & DOHME CORP. , MSD R & D (CHINA) CO., LTD. , ACTON, John J., III , BAO, Jianming , DENG, Qiaolin , EGBERTSON, Melissa , FERGUSON, Ronald , GAO, Xiaolei , HARRISON, Scott T. , HENDERSON, Timothy J. , KNOWLES, Sandra L. , LO, Michael Man-Chu , MAZZOLA, Robert D., Jr , SELYUTIN, Oleg , ZHANG, Fengqi , NA, Meng , SUZUKI, Takao
- 申请人地址： 126 East Lincoln Avenue, Rahway New Jersey 07065 US
- 专利权人： MERCK SHARP & DOHME CORP.,MSD R & D (CHINA) CO., LTD.,ACTON, John J., III,BAO, Jianming,DENG, Qiaolin,EGBERTSON, Melissa,FERGUSON, Ronald,GAO, Xiaolei,HARRISON, Scott T.,HENDERSON, Timothy J.,KNOWLES, Sandra L.,LO, Michael Man-Chu,MAZZOLA, Robert D., Jr,SELYUTIN, Oleg,ZHANG, Fengqi,NA, Meng,SUZUKI, Takao
- 当前专利权人： MERCK SHARP & DOHME CORP.,MSD R & D (CHINA) CO., LTD.,ACTON, John J., III,BAO, Jianming,DENG, Qiaolin,EGBERTSON, Melissa,FERGUSON, Ronald,GAO, Xiaolei,HARRISON, Scott T.,HENDERSON, Timothy J.,KNOWLES, Sandra L.,LO, Michael Man-Chu,MAZZOLA, Robert D., Jr,SELYUTIN, Oleg,ZHANG, Fengqi,NA, Meng,SUZUKI, Takao
- 当前专利权人地址： 126 East Lincoln Avenue, Rahway New Jersey 07065 US
- 代理机构： WU, FENG & ZHANG
- 主分类号： C07D231/10
- IPC分类号： C07D231/10 ; C07D231/02 ; C07D401/14 ; A61K31/455 ; A61P25/00
摘要：
Provided are pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. Provided is also use of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. Provided are also compositions comprising these compounds. Provided is also use of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D231/00 | 杂环化合物，含1,2-二唑或氢化1,2-二唑环 |
| --------C07D231/02 | .不与其他环稠合 |
| ----------C07D231/10 | ..环原子间或环原子与非环原子间有两个或3个双键 |