发明申请
WO2018237253A1 METHOD OF IMAGING IN VIVO TISSUES USING NANOPARTICLES COMPRISING A REFERENCE DYE AND A SENSOR DYE.
审中-公开
基本信息:
- 专利标题： METHOD OF IMAGING IN VIVO TISSUES USING NANOPARTICLES COMPRISING A REFERENCE DYE AND A SENSOR DYE.
- 申请号：PCT/US2018/038973 申请日：2018-06-22
- 公开(公告)号：WO2018237253A1 公开(公告)日：2018-12-27
- 发明人： BRADBURY, Michelle S. , WIESNER, Ulrich , OVERHOLTZER, Michael , ABU-RUSTUM, Nadeem R. , MADAJEWSKI, Brian
- 申请人： MEMORIAL SLOAN KETTERING CANCER CENTER , CORNELL UNIVERSITY
- 申请人地址： 1275 York Avenue New York, New York 10065 US
- 专利权人： MEMORIAL SLOAN KETTERING CANCER CENTER,CORNELL UNIVERSITY
- 当前专利权人： MEMORIAL SLOAN KETTERING CANCER CENTER,CORNELL UNIVERSITY
- 当前专利权人地址： 1275 York Avenue New York, New York 10065 US
- 代理机构： MONROE, Margo R. et al.
- 优先权： US62/524,441 20170623; US62/590,507 20171124
- 主分类号： G01N21/64
- IPC分类号： G01N21/64 ; A61K49/00
摘要：
Described herein are systems and methods for intracellular imaging, assessment, and/or treatment of tissue before, during, and/or after surgical procedures using nanoparticles (e.g., less than 50 nanometers in diameter, e.g., photoswitchable nanoparticles) and/or a super-resolution microscope system. The present disclosure describes nanoparticles (e.g., nanosensors and photoswitchable nanoparticles) that are used to monitor and/or track changes in environmental conditions and/or analytes in the cellular microenvironment before, during, and/or after surgical procedures. The present disclosure also describes systems and methods that provide information related to the distribution and/or delivery of photoswitchable nanoparticles at super resolution (e.g., using super-resolution microscopy).
IPC结构图谱:
| G | 物理 |
| --G01 | 测量；测试 |
| ----G01N | 借助于测定材料的化学或物理性质来测试或分析材料 |
| ------G01N21/00 | 利用光学手段，即利用红外光、可见光或紫外光来测试或分析材料 |
| --------G01N21/01 | .便于进行光学测试的装置或仪器 |
| ----------G01N21/63 | ..光学激发的 |
| ------------G01N21/64 | ...荧光；磷光 |