基本信息:
- 专利标题： LIPID DELIVERY OF THERAPEUTIC AGENTS TO ADIPOSE TISSUE
- 申请号：PCT/US2018/027655 申请日：2018-04-13
- 公开(公告)号：WO2018191719A1 公开(公告)日：2018-10-18
- 发明人： LIN, Paulo, Jia Ching , TAM, Ying
- 申请人： ACUITAS THERAPEUTICS, INC.
- 申请人地址： 6190 Agronomy Road, Suite 402 University of British Columbia - KETR Vancouver, British Columbia V6T 1W5 CA
- 专利权人： ACUITAS THERAPEUTICS, INC.
- 当前专利权人： ACUITAS THERAPEUTICS, INC.
- 当前专利权人地址： 6190 Agronomy Road, Suite 402 University of British Columbia - KETR Vancouver, British Columbia V6T 1W5 CA
- 代理机构： LIGON, Toby, J. et al.
- 优先权： US62/485,278 20170413; US62/485,736 20170414; US62/491,664 20170428; US62/491,659 20170428; US62/546,227 20170816; US62/595,497 20171206
- 主分类号： C07C211/09
- IPC分类号： C07C211/09 ; C07C211/10 ; C07C211/11 ; C07C215/08 ; C07C215/10 ; C07C215/12 ; C07C233/36 ; A61K31/7105 ; A61K47/18 ; A61K47/69 ; A61K31/20 ; A61K31/21 ; A61P3/08
摘要：
A method of treating a disease mediated by protein expression in adipose tissue by intraperitoneally administering a composition comprising a lipid nanoparticle encapsulating or associated with a therapeutic agent (e.g., a nucleic acid), thereby delivering the therapeutic agent to adipose tissue of the subject and altering protein expression in the adipose tissue is provided herein. A method for delivering a therapeutic agent to adipose tissue of a subject in need thereof is also provided.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C211/00 | 含有与碳架连接的氨基的化合物 |
| --------C07C211/01 | .与非环碳原子连接的氨基 |
| ----------C07C211/02 | ..无环饱和碳架的 |
| ------------C07C211/09 | ...二胺 |