基本信息:
- 专利标题： THERMALLY-CLEAVABLE PROTECTING AND LINKER GROUPS
- 申请号：PCT/GB2018/050975 申请日：2018-04-12
- 公开(公告)号：WO2018189546A1 公开(公告)日：2018-10-18
- 发明人： CROSBY, Stuart Richard , JENNISON, Mathew , BRENNAN, Joseph
- 申请人： EVONETIX LTD
- 申请人地址： Suite 6 Science Village Chesterford Research Park Little Chesterford Essex CB10 1XL GB
- 专利权人： EVONETIX LTD
- 当前专利权人： EVONETIX LTD
- 当前专利权人地址： Suite 6 Science Village Chesterford Research Park Little Chesterford Essex CB10 1XL GB
- 代理机构： WONG, Kit
- 优先权： GB1705925.4 20170412
- 主分类号： C07D207/09
- IPC分类号： C07D207/09 ; C07D211/26 ; C07H1/00 ; C07H19/073 ; C07H19/173 ; C07H21/00 ; C07H23/00
摘要：
The present invention relates to chemical linkers and protecting groups, compounds and compositions containing the chemical linkers or protecting groups, and intermediates and processes that can be used to prepare them. The chemical linkers and protecting groups are based on pyrrolidine and piperidine activating groups, which undergo intramolecular cyclisation upon heating with release of carbon dioxide, thereby releasing the organic compound from a substrate. In particular, those chemical linkers and protecting groups are useful in the solid phase synthesis of oligonucleotides according to the following representative schemes.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D207/00 | 杂环化合物，含五元环，不与其他环稠合，带1个氮原子作为惟一的环杂原 |
| --------C07D207/02 | .只有氧或碳原子直接连在环氮原子上 |
| ----------C07D207/04 | ..环原子间或环原子与非环原子间无双键 |
| ------------C07D207/08 | ...带有被杂原子取代的烃基，连在环碳原子上 |
| --------------C07D207/09 | ....被非硝基氮原子取代的基 |