基本信息:
- 专利标题： COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING CANCERS
- 申请号：PCT/US2018/025530 申请日：2018-03-30
- 公开(公告)号：WO2018183936A1 公开(公告)日：2018-10-04
- 发明人： CORSELLO, Steven M. , GOLUB, Todd R. , STEFAN, Eric , HILGRAF, Robert
- 申请人： CORSELLO, Steven M. , GOLUB, Todd R. , THE BROAD INSTITUTE, INC. , DANA-FARBER CANCER INSTITUTE, INC. , STEFAN, Eric , HILGRAF, Robert
- 申请人地址： c/o Dana-Farber Cancer Institute, Inc. 450 Brookline Avenue Boston, Massachusetts 02215 US
- 专利权人： CORSELLO, Steven M.,GOLUB, Todd R.,THE BROAD INSTITUTE, INC.,DANA-FARBER CANCER INSTITUTE, INC.,STEFAN, Eric,HILGRAF, Robert
- 当前专利权人： CORSELLO, Steven M.,GOLUB, Todd R.,THE BROAD INSTITUTE, INC.,DANA-FARBER CANCER INSTITUTE, INC.,STEFAN, Eric,HILGRAF, Robert
- 当前专利权人地址： c/o Dana-Farber Cancer Institute, Inc. 450 Brookline Avenue Boston, Massachusetts 02215 US
- 代理机构： HUNTER-ENSOR, Melissa
- 优先权： US62/479,946 20170331
- 主分类号： A61K31/4965
- IPC分类号： A61K31/4965 ; A61K31/497 ; A61K31/498
摘要：
The present invention includes CSNK1A1 inhibitors that are useful in treating or preventing a cancer in a subject. In certain embodiments, the cancer comprises a hematological cancer, such as but not limited to acute myeloid leukemia (AML) and/or MDS (myelodysplastic syndrome, including 5q-MDS). In other embodiments, the cancer comprises colon cancer.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/4965 | ....非稠合的吡嗪 |