发明申请
WO2018170492A1 KAPPA OPIOID RECEPTOR ANTAGONISTS AND PRODUCTS AND METHODS RELATED THERETO
审中-公开
基本信息:
- 专利标题： KAPPA OPIOID RECEPTOR ANTAGONISTS AND PRODUCTS AND METHODS RELATED THERETO
- 申请号：PCT/US2018/023027 申请日：2018-03-16
- 公开(公告)号：WO2018170492A1 公开(公告)日：2018-09-20
- 发明人： ROBERTS, Edward , GUERRERO, Miguel A. , URBANO, Mariangela , ROSEN, Hugh , JONES, Rob , LAXAMANA, Candace Mae , ZHAO, Xianrui , TURTLE, Eric Douglas
- 申请人： THE SCRIPPS RESEARCH INSTITUTE , BLACKTHORN THERAPEUTICS, INC. , ROBERTS, Edward , GUERRERO, Miguel A. , URBANO, Mariangela , ROSEN, Hugh , JONES, Rob , LAXAMANA, Candace Mae , ZHAO, Xianrui , TURTLE, Eric Douglas
- 申请人地址： 10550 North Torry Pines Rd La Jolla, California 92037 US
- 专利权人： THE SCRIPPS RESEARCH INSTITUTE,BLACKTHORN THERAPEUTICS, INC.,ROBERTS, Edward,GUERRERO, Miguel A.,URBANO, Mariangela,ROSEN, Hugh,JONES, Rob,LAXAMANA, Candace Mae,ZHAO, Xianrui,TURTLE, Eric Douglas
- 当前专利权人： THE SCRIPPS RESEARCH INSTITUTE,BLACKTHORN THERAPEUTICS, INC.,ROBERTS, Edward,GUERRERO, Miguel A.,URBANO, Mariangela,ROSEN, Hugh,JONES, Rob,LAXAMANA, Candace Mae,ZHAO, Xianrui,TURTLE, Eric Douglas
- 当前专利权人地址： 10550 North Torry Pines Rd La Jolla, California 92037 US
- 代理机构： COOPER, Michael, P. et al.
- 优先权： US62/473,209 20170317; US62/585,447 20171113; US62/609,960 20171222
- 主分类号： C07D413/14
- IPC分类号： C07D413/14 ; A61K31/4709 ; A61P25/24
摘要：
Compounds are provided that antagonize the kappa-opioid receptor (KOR) and products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof: (I) wherein X, Y, R 1 , R 2 , R 4 , R 5 R 6 , R 7 , R 8 and R 11 are as defined herein.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D413/00 | 杂环化合物，含两个或更多个杂环，至少有1个环有氮原子和氧原子作为仅有的杂环原子 |
| --------C07D413/14 | .含有3个或更多个杂环 |