基本信息:
- 专利标题： INNATE IMMUNE CELL INDUCIBLE BINDING PROTEINS AND METHODS OF USE
- 申请号：PCT/US2018/014396 申请日：2018-01-19
- 公开(公告)号：WO2018136725A1 公开(公告)日：2018-07-26
- 发明人： BAEUERLE, Patrick , DUBRIDGE, Robert B. , WESCHE, Holger , EVNIN, Luke , GUENOT, Jeanmarie , AUSTIN, Richard J. , LEMON, Bryan D.
- 申请人： HARPOON THERAPEUTICS, INC.
- 申请人地址： 4000 Shoreline Court Suite 250 South San Francisco, California 94080 US
- 专利权人： HARPOON THERAPEUTICS, INC.
- 当前专利权人： HARPOON THERAPEUTICS, INC.
- 当前专利权人地址： 4000 Shoreline Court Suite 250 South San Francisco, California 94080 US
- 代理机构： LIN, Clark Y.
- 优先权： US62/448,342 20170119
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C07K16/46 ; C07K19/00
摘要：
Provided herein are conditionally activated antigen-binding proteins comprising a protease-activated domain binding to an innate immune cell, at least one half-life extension domain, and two or more domains binding to one or more target antigens. Also provided are pharmaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such antigen-binding proteins. Also disclosed are methods of using the disclosed antigen-binding proteins in the prevention, and/or treatment diseases, conditions and disorders.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K16/00 | 免疫球蛋白，例如，单克隆或多克隆抗体 |
| --------C07K16/18 | .来自动物或人的抵抗物质 |
| ----------C07K16/28 | ..抗受体，细胞表面抗原或细胞表面决定因子 |