基本信息:
- 专利标题： IONIZABLE CATIONIC LIPID FOR RNA DELIVERY
- 申请号：PCT/US2017/067756 申请日：2017-12-20
- 公开(公告)号：WO2018119163A1 公开(公告)日：2018-06-28
- 发明人： PAYNE, Joseph, E. , CHIVUKULA, Padmanabh , TANIS, Steven, P. , KARMALI, Priya
- 申请人： PAYNE, Joseph, E. , CHIVUKULA, Padmanabh , TANIS, Steven, P. , KARMALI, Priya
- 申请人地址： 10628 Science Center Drive, Suite 200 San Diego, CA 92121 US
- 专利权人： PAYNE, Joseph, E.,CHIVUKULA, Padmanabh,TANIS, Steven, P.,KARMALI, Priya
- 当前专利权人： PAYNE, Joseph, E.,CHIVUKULA, Padmanabh,TANIS, Steven, P.,KARMALI, Priya
- 当前专利权人地址： 10628 Science Center Drive, Suite 200 San Diego, CA 92121 US
- 代理机构： KNUDSEN, Peter, J.
- 优先权： USPCT/US2017/015886 20170131; US15/387,067 20161221
- 主分类号： C07C333/04
- IPC分类号： C07C333/04
摘要：
What is described is a compound of formula (I) consisting of a compound in which R1 is a branched chain alkyl consisting of 10 to 31 carbons; R2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons, or a branched chain alkyl consisting of 10 to 31 carbons; L1 and L2 are the same or different, each a linear alkane of 1 to 20 carbons or a linear alkene of 2 to 20 carbons; X1 is S or O; R3 is a linear or branched alkylene consisting of 1 to 6 carbons; and R4 and R5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.