基本信息:
- 专利标题： HETEROCYCLIC COMPOUNDS AS HIV PROTEASE INHIBITORS
- 申请号：PCT/US2017/067163 申请日：2017-12-19
- 公开(公告)号：WO2018118829A1 公开(公告)日：2018-06-28
- 发明人： MCKITTRICK, Brian , CALDWELL, John, P. , MCCAULEY, John, A. , VACCARO, Henry , CHAN, Tin-Yau , KIM, Hyunjin , SMITH, Elizabeth , HONG, Liwu , KHAN, Tanweer , YING, Shihong , WANG, Hongwu , WILLIAMS, Peter, D. , KIM, Jae-Hun , NOLT, M. Brad , CAPLEN, Mary Ann
- 申请人： MERCK SHARP & DOHME CORP. , MCKITTRICK, Brian , CALDWELL, John, P. , MCCAULEY, John, A. , VACCARO, Henry , CHAN, Tin-Yau , KIM, Hyunjin , SMITH, Elizabeth , HONG, Liwu , KHAN, Tanweer , YING, Shihong , WANG, Hongwu , WILLIAMS, Peter, D. , KIM, Jae-Hun , NOLT, M. Brad , CAPLEN, Mary Ann
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 专利权人： MERCK SHARP & DOHME CORP.,MCKITTRICK, Brian,CALDWELL, John, P.,MCCAULEY, John, A.,VACCARO, Henry,CHAN, Tin-Yau,KIM, Hyunjin,SMITH, Elizabeth,HONG, Liwu,KHAN, Tanweer,YING, Shihong,WANG, Hongwu,WILLIAMS, Peter, D.,KIM, Jae-Hun,NOLT, M. Brad,CAPLEN, Mary Ann
- 当前专利权人： MERCK SHARP & DOHME CORP.,MCKITTRICK, Brian,CALDWELL, John, P.,MCCAULEY, John, A.,VACCARO, Henry,CHAN, Tin-Yau,KIM, Hyunjin,SMITH, Elizabeth,HONG, Liwu,KHAN, Tanweer,YING, Shihong,WANG, Hongwu,WILLIAMS, Peter, D.,KIM, Jae-Hun,NOLT, M. Brad,CAPLEN, Mary Ann
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 代理机构： MERCK SHARP & DOHME CORP.
- 优先权： US62/437,919 20161222
- 主分类号： A61K31/4178
- IPC分类号： A61K31/4178 ; C07D403/06 ; C07D493/04
摘要：
The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/415 | ....1,2二唑 |
| ----------------A61K31/4178 | .....未稠合的并含有另外的杂环的，例如毛果芸香碱、硝基呋喃妥英 |