发明申请
WO2018118736A1 6,5-FUSED HETEROARYL PIPERIDINE ETHER ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR
审中-公开
基本信息:
- 专利标题： 6,5-FUSED HETEROARYL PIPERIDINE ETHER ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR
- 申请号：PCT/US2017/066921 申请日：2017-12-18
- 公开(公告)号：WO2018118736A1 公开(公告)日：2018-06-28
- 发明人： GAO, Xiaolei , KNOWLES, Sandra, L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert, D., Jr. , ONDEYKA, Debra, L.
- 申请人： MERCK SHARP & DOHME CORP. , GAO, Xiaolei , KNOWLES, Sandra, L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert, D., Jr. , ONDEYKA, Debra, L.
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 专利权人： MERCK SHARP & DOHME CORP.,GAO, Xiaolei,KNOWLES, Sandra, L.,LI, Chunsing,LO, Michael Man-Chu,MAZZOLA, Robert, D., Jr.,ONDEYKA, Debra, L.
- 当前专利权人： MERCK SHARP & DOHME CORP.,GAO, Xiaolei,KNOWLES, Sandra, L.,LI, Chunsing,LO, Michael Man-Chu,MAZZOLA, Robert, D., Jr.,ONDEYKA, Debra, L.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 代理机构： MERCK SHARP & DOHME CORP.
- 优先权： CNPCT/CN2016/111527 20161222
- 主分类号： A61K31/4196
- IPC分类号： A61K31/4196 ; A61K31/435 ; A61K31/445 ; C07D249/08 ; C07D401/02 ; C07D401/04
摘要：
The present invention is directed to 6,5-fused heteroarylpiperidine ether compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/4196 | ....1,2,4三唑 |