发明申请
WO2018112842A1 6,6-FUSED HETEROARYL PIPERIDINE ETHER ALLOSTERIC MODULATORS OF M4 MUSCARINIC ACETYLCHOLINE RECEPTOR
审中-公开
基本信息:
- 专利标题： 6,6-FUSED HETEROARYL PIPERIDINE ETHER ALLOSTERIC MODULATORS OF M4 MUSCARINIC ACETYLCHOLINE RECEPTOR
- 申请号：PCT/CN2016/111529 申请日：2016-12-22
- 公开(公告)号：WO2018112842A1 公开(公告)日：2018-06-28
- 发明人： GAO, Xiaolei , KNOWLES, Sandra L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert D. Jr. , TONG, Ling
- 申请人： MERCK SHARP & DOHME CORP. , GAO, Xiaolei , KNOWLES, Sandra L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert D. Jr. , TONG, Ling
- 申请人地址： 126 East Lincoln Avenue Rahway New Jersey 07065 US
- 专利权人： MERCK SHARP & DOHME CORP.,GAO, Xiaolei,KNOWLES, Sandra L.,LI, Chunsing,LO, Michael Man-Chu,MAZZOLA, Robert D. Jr.,TONG, Ling
- 当前专利权人： MERCK SHARP & DOHME CORP.,GAO, Xiaolei,KNOWLES, Sandra L.,LI, Chunsing,LO, Michael Man-Chu,MAZZOLA, Robert D. Jr.,TONG, Ling
- 当前专利权人地址： 126 East Lincoln Avenue Rahway New Jersey 07065 US
- 代理机构： WU, FENG & ZHANG CO.
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; A61K31/435 ; A61P25/18
摘要：
Disclosed are 6, 6-fused heteroarylpiperidine ether compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor and compositions comprising these compounds. Disclosed herein also are uses of these compounds and compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D401/00 | 杂环化合物，含有两个或更多个杂环，以氮原子作为仅有的杂环原子，至少有1个环是仅含有1个氮原子的六元环 |
| --------C07D401/14 | .含有3个或更多个杂环 |