发明申请
WO2018085171A1 SUBSTITUTED BICYCLIC HETEROARYL ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
审中-公开
基本信息:
- 专利标题： SUBSTITUTED BICYCLIC HETEROARYL ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
- 专利标题（中）：烟碱型乙酰胆碱受体的双环杂交修饰
- 申请号：PCT/US2017/058933 申请日：2017-10-30
- 公开(公告)号：WO2018085171A1 公开(公告)日：2018-05-11
- 发明人： CROWLEY, Brendan, M. , BELL, Ian, M. , HARVEY, Andrew John , SHIPE, William, D. , LEAVITT, Kenneth, J. , SANDERS, John, M. , GUIADEEN, Deodial, G. , SUEN, Linda, M. , GRESHOCK, Thomas, J. , RADA, Vanessa, L.
- 申请人： MERCK SHARP & DOHME CORP. , CROWLEY, Brendan, M. , BELL, Ian, M. , HARVEY, Andrew John , SHIPE, William, D. , LEAVITT, Kenneth, J. , SANDERS, John, M. , GUIADEEN, Deodial, G. , SUEN, Linda, M. , GRESHOCK, Thomas, J. , RADA, Vanessa, L.
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 专利权人： MERCK SHARP & DOHME CORP.,CROWLEY, Brendan, M.,BELL, Ian, M.,HARVEY, Andrew John,SHIPE, William, D.,LEAVITT, Kenneth, J.,SANDERS, John, M.,GUIADEEN, Deodial, G.,SUEN, Linda, M.,GRESHOCK, Thomas, J.,RADA, Vanessa, L.
- 当前专利权人： MERCK SHARP & DOHME CORP.,CROWLEY, Brendan, M.,BELL, Ian, M.,HARVEY, Andrew John,SHIPE, William, D.,LEAVITT, Kenneth, J.,SANDERS, John, M.,GUIADEEN, Deodial, G.,SUEN, Linda, M.,GRESHOCK, Thomas, J.,RADA, Vanessa, L.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 代理机构： MERCK SHARP & DOHME CORP.
- 优先权： US62/415,788 20161101; US62/558,606 20170914
- 主分类号： A61K31/18
- IPC分类号： A61K31/18 ; C07C311/08
摘要：
The present disclosure relates to compounds of formula (I) that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation.
摘要（中）：
本发明涉及可用作α7nAChR调节剂的式（I）化合物，包含此类化合物的组合物，以及此类化合物用于预防，治疗或改善疾病，特别是疾病 的中枢神经系统，例如阿尔茨海默病，帕金森病和精神分裂症中的认知障碍，以及L-DOPA诱导的运动障碍和炎症。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/045 | .羟基化合物，例如醇类；其盐类，例如醇化物 |
| ----------A61K31/18 | ..磺胺类 |