The present disclosure relates to a device (1) for sampling and/or injection of a radioactive solution (S) in a vial (2), wherein the vial (2) comprises an opening closed by a puncturable closure member (3). The device (1) comprises a container (7) adapted to receive said vial (2) and a vial adaptor (4), said vial adaptor (4) having a longitudinal axis (L1), provided at a first end (41) with a hollow spike (42) adapted to pierce said puncturable closure member (3) when the vial adaptor (4) is mounted on the vial (2), and at a second end (43) with connection means (5) adapted for its removable connection to a syringe (6), the container (7) comprising: - a container body (71) adapted to receive said vial (2), the container body (71) having an opening (711), and - a vial adaptor support structure (72) configured for being mounted onto the opening (711) of the container body (71), and comprising retention means configured for enabling releasable retention of said vial adaptor (4) within said vial adaptor support structure (72), and wherein the vial adaptor support structure (72) and the container body (71) are made at least partially of a radioprotective material for providing protection against ionizing radiation.