基本信息:
- 专利标题： MAMMALIAN CELL IN VITRO TOPOLOGICAL NEURON NETWORK
- 专利标题（中）：哺乳动物细胞体外拓扑神经元网络
- 申请号：PCT/US2016/066014 申请日：2016-12-09
- 公开(公告)号：WO2017100705A1 公开(公告)日：2017-06-15
- 发明人： PETCAVICH, Robert John
- 申请人： PETCAVICH, Robert John
- 申请人地址： 10 Acorn Cluster Court The Woodlands, Texas 77301 US
- 专利权人： PETCAVICH, Robert John
- 当前专利权人： PETCAVICH, Robert John
- 当前专利权人地址： 10 Acorn Cluster Court The Woodlands, Texas 77301 US
- 代理机构： BIANCHI, Timothy E. et al.
- 优先权： US62/265,399 20151209
- 主分类号： C12N5/0793
- IPC分类号： C12N5/0793 ; C12N5/00 ; C12M1/42 ; C12M1/12 ; G01N33/483 ; G01N33/50
摘要：
A method of creating a three-dimensional surface topography network for the containment and growth of mammalian neuron cells for high throughput screening of potential biologically active drug compounds is provided. In the present disclosure an n x n array of wells is created on a carrier substrate that contains both wells and interconnected channels between wells to facilitate axon growth between neuron cells and subsequently the creation of a living interactive neuron network in vitro that emulates in vivo neuron behavior.
摘要（中）：
提供了用于遏制和生长哺乳动物神经元细胞的三维表面形貌网络的方法，用于高通量筛选潜在的生物活性药物化合物。 在本公开中，在载体基底上产生nxn个孔阵列，所述载体基底包含孔和孔之间的互连通道以促进神经元细胞之间的轴突生长，并随后体外模拟体内神经元行为创建活的交互式神经元网络。