发明申请
WO2017039445A1 AN IN VITRO METHOD OF DIFFERENTIATING A HUMAN PLURIPOTENT STEM CELL POPULATION INTO A CARDIOMYOCYTE CELL POPULATION
审中-公开
基本信息:
- 专利标题： AN IN VITRO METHOD OF DIFFERENTIATING A HUMAN PLURIPOTENT STEM CELL POPULATION INTO A CARDIOMYOCYTE CELL POPULATION
- 专利标题（中）：将人类群体干细胞群体分化为心脏细胞群体的体外方法
- 申请号：PCT/NL2016/050609 申请日：2016-08-31
- 公开(公告)号：WO2017039445A1 公开(公告)日：2017-03-09
- 发明人： BRAAM, Stefan Robbert , GRANDELA, Ana Catarina Martins
- 申请人： PLURIOMICS B.V.
- 申请人地址： 8, Galileiweg 2333 BD Leiden NL
- 专利权人： PLURIOMICS B.V.
- 当前专利权人： PLURIOMICS B.V.
- 当前专利权人地址： 8, Galileiweg 2333 BD Leiden NL
- 代理机构： RAGGERS, R.J.
- 优先权： NL2015385 20150901
- 主分类号： C12N5/077
- IPC分类号： C12N5/077
摘要：
The current invention relates to a method of differentiation of human pluripotent stem cells into a human stem-cell derived population of cardiomyocytes. The method comprises the use of specific combination of steps and compounds to induce and/or promote differentiation. The method also comprises steps directed to further maturation of the cardiomyocytes obtained with the method of the invention. Also provided are kits for use in a method of differentiation as well as cell populations obtainable with the method disclosed.
摘要（中）：
本发明涉及将人多能干细胞分化为人类干细胞来源的心肌细胞群的方法。 该方法包括使用步骤和化合物的特定组合来诱导和/或促进分化。 该方法还包括通过本发明的方法获得的进一步成熟心肌细胞的步骤。 还提供了用于分化方法的试剂盒以及可用所公开的方法获得的细胞群。