基本信息:
- 专利标题： A NOVEL PROCESS FOR THE PREPARATION OF ETHACRYNATE SODIUM
- 专利标题（中）：用于制备乙酸钠的新方法
- 申请号：PCT/IN2016/050151 申请日：2016-05-21
- 公开(公告)号：WO2016189549A1 公开(公告)日：2016-12-01
- 发明人： PULLAGURLA, Manik Reddy , NANDA KUMAR, Mecheril Valsan , GRUDANTI, Varadaraju Tirumala , GAJJALA, Bharath Reddy , RANGISETTY, Jagadeesh Babu
- 申请人： BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.
- 申请人地址： Plot No. 23, 3rd Floor, TIE, 1st Phase, Balanagar, Hyderabad 500037 IN
- 专利权人： BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.
- 当前专利权人： BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.
- 当前专利权人地址： Plot No. 23, 3rd Floor, TIE, 1st Phase, Balanagar, Hyderabad 500037 IN
- 代理机构： HASAN, Afzal et al.
- 优先权： IN2573/CHE/2015 20150522
- 主分类号： A61K31/192
- IPC分类号： A61K31/192
摘要：
The present invention describes a novel process for the preparation of Ethacrynate sodium. The process involves the treatment of Ethacrynic acid with equimolar amount of sodium salt of alkyl carboxylic acid in the presence of organic solvents. The product obtained by the process is substantially pure form (purity greater than 99%) and limits known impurities below 0.1% w/w. The process also relates to a crystalline form of Ethacrynate sodium and a process for its preparation. The process is efficient and cost effective method for the commercial scale production of substantially pure stable form of Ethacrynate sodium.
摘要（中）：
本发明描述了制备Ethacrynate钠的新方法。 该方法涉及在有机溶剂存在下用等摩尔量的烷基羧酸钠盐处理Ethacrynic酸。 通过该方法获得的产物是基本上纯的形式（纯度大于99％），并限制已知的杂质低于0.1％w / w。 该方法还涉及Ethacrynate钠的结晶形式及其制备方法。 该方法是用于商业规模生产基本上纯的稳定形式的乙酸钠的有效且成本有效的方法。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/045 | .羟基化合物，例如醇类；其盐类，例如醇化物 |
| ----------A61K31/19 | ..羧酸；例如丙戊酸 |
| ------------A61K31/192 | ...含芳族基团的，例如舒林酸、2芳基丙酸、依他尼酸 |