基本信息:
- 专利标题： DEVICES AND METHODS FOR DETECTION OF BIOMARKERS
- 专利标题（中）：用于检测生物标志物的装置和方法
- 申请号：PCT/US2016/030959 申请日：2016-05-05
- 公开(公告)号：WO2016179378A1 公开(公告)日：2016-11-10
- 发明人： SAXENA, Sanjeev , BURTON, Louis, Eugene , LAU, Francis, William , CUPPOLETTI, Andrea , BHATIA, Rajinder, Kaur
- 申请人： POC MEDICAL SYSTEMS INC.
- 申请人地址： 3037 Independence Drive, Suite A Livermore, CA 94551 US
- 专利权人： POC MEDICAL SYSTEMS INC.
- 当前专利权人： POC MEDICAL SYSTEMS INC.
- 当前专利权人地址： 3037 Independence Drive, Suite A Livermore, CA 94551 US
- 代理机构： JOHNSON, Kirsten
- 优先权： US62/202,353 20150807; US62/183,294 20150623; US62/157,878 20150506
- 主分类号： G01N33/543
- IPC分类号： G01N33/543
摘要：
Devices for detecting biomarkers in a sample and methods for detecting such biomarkers are discussed. The biomarkers may be associated with a particular disease such as breast cancer or another health condition. The devices may contain a disc including a plurality of microfluidic channels extending in a radial direction of the disc, the microfluidic channels pre-loaded with a plurality of capture molecules specific to at least one biomarker. The methods may include introducing a fluid sample into at least one microfluidic channel of a disc, rotating the disc, such that the fluid sample flows radially outward through the at least one microfluidic channel to combine with capture molecules specific to at least one biomarker, and detecting a signal from the disc indicative of a presence of the at least one biomarker contained in the fluid sample.
摘要（中）：
讨论了用于检测样品中生物标志物的装置和用于检测这些生物标志物的方法。 生物标志物可能与特定疾病如乳腺癌或其他健康状况相关。 装置可以包含盘，其包括在盘的径向方向上延伸的多个微流体通道，预先加载有至少一种生物标志物特异性的多个捕获分子的微流体通道。 所述方法可以包括将流体样品引入盘的至少一个微流体通道，旋转盘，使得流体样品径向向外流过所述至少一个微流体通道以与特定于至少一个生物标志物的捕获分子组合，以及 检测来自所述盘的指示所述流体样品中包含的所述至少一种生物标志物的存在的信号。
IPC结构图谱:
| G | 物理 |
| --G01 | 测量；测试 |
| ----G01N | 借助于测定材料的化学或物理性质来测试或分析材料 |
| ------G01N33/00 | 利用不包括在G01N1/00至G01N31/00组中的特殊方法来研究或分析材料 |
| --------G01N33/48 | .生物物质，例如血、尿（G01N33/02至G01N33/14，G01N33/26，G01N33/44，G01N33/46优先；种子发芽能力测定入A01C1/02）；血球计数器 |
| ----------G01N33/483 | ..生物物质的物理分析 |
| ------------G01N33/53 | ...免疫测定法；生物特有的结合方法的测定；相应的生物物质 |
| --------------G01N33/543 | ....用不溶解的载体固定免疫化学物品 |