发明申请
WO2016095037A1 MODULATION AND DETECTION OF A NEURONAL ALTERNATIVE SPLICING REGULATORY NETWORK FOR TREATMENT AND DIAGNOSIS OF NEUROLOGICAL DISORDERS
审中-公开
基本信息:
- 专利标题： MODULATION AND DETECTION OF A NEURONAL ALTERNATIVE SPLICING REGULATORY NETWORK FOR TREATMENT AND DIAGNOSIS OF NEUROLOGICAL DISORDERS
- 专利标题（中）：调节和检测神经元替代性分离法规网络，用于治疗和诊断神经病
- 申请号：PCT/CA2015/051328 申请日：2015-12-15
- 公开(公告)号：WO2016095037A1 公开(公告)日：2016-06-23
- 发明人： BLENCOWE, Benjamin J. , QUESNEL-VALLIERES, Mathieu , IRIMIA, Manuel , RAJ, Bushra , CORDES, Sabine P.
- 申请人： BLENCOWE, Benjamin J. , QUESNEL-VALLIERES, Mathieu , IRIMIA, Manuel , RAJ, Bushra , CORDES, Sabine P.
- 申请人地址： 56 Lippincott Street Toronto, Ontario M5T 2R5 CA
- 专利权人： BLENCOWE, Benjamin J.,QUESNEL-VALLIERES, Mathieu,IRIMIA, Manuel,RAJ, Bushra,CORDES, Sabine P.
- 当前专利权人： BLENCOWE, Benjamin J.,QUESNEL-VALLIERES, Mathieu,IRIMIA, Manuel,RAJ, Bushra,CORDES, Sabine P.
- 当前专利权人地址： 56 Lippincott Street Toronto, Ontario M5T 2R5 CA
- 代理机构： BERESKIN & PARR LLP/S.E.N.C.R.L., S.R.L.
- 优先权： US62/093,192 20141217
- 主分类号： C12N5/071
- IPC分类号： C12N5/071 ; A01K67/027 ; A61K31/7088 ; A61K38/46 ; A61K39/395 ; A61P25/00 ; A61P25/18 ; C12N15/00 ; C12N15/12 ; C12N5/079 ; C12N5/10 ; C12Q1/00 ; C12Q1/68 ; G01N33/48 ; G06F19/10
摘要：
Methods for treatment and diagnosis of neurological disorders such as autism and autism spectrum disorder are disclosed. Also disclosed are modulators of alternative splicing regulators SRRM4 and/or SRRM3 for treating neurological disorders. Further disclosed are agents that modulate the expression of at least one splice variant for treating neurological disorders. Mouse models of neurological disorders having increased or decreased expression of SRRM4 and/or SRRM3 are also disclosed.
摘要（中）：
公开了治疗和诊断自闭症和自闭症谱系障碍的神经障碍的方法。 还公开了用于治疗神经障碍的可选剪接调节物SRRM4和/或SRRM3的调节剂。 还公开了调节用于治疗神经障碍的至少一种剪接变体的表达的试剂。 还公开了具有SRRM4和/或SRRM3的表达增加或减少的神经障碍的小鼠模型。