基本信息:
- 专利标题： TREATMENT OF CANCER USING A CD33 CHIMERIC ANTIGEN RECEPTOR
- 专利标题（中）：使用CD33基因抗原受体治疗癌症
- 申请号：PCT/US2015/041390 申请日：2015-07-21
- 公开(公告)号：WO2016014576A1 公开(公告)日：2016-01-28
- 发明人： BROGDON, Jennifer , EBERSBACH, Hilmar , GILL, Saar , GLASS, David , HUBER, Thomas , JASCUR, Julia , KENDERIAN, Saad , MANNICK, Joan , MILONE, Michael, C. , MURPHY, Leon , RICHARDSON, Celeste , SINGH, Reshma , SONG, Huijuan , WU, Qilong , ZHANG, Jiquan
- 申请人： NOVARTIS AG , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , BROGDON, Jennifer , EBERSBACH, Hilmar , GILL, Saar , GLASS, David , HUBER, Thomas , JASCUR, Julia , KENDERIAN, Saad , MANNICK, Joan , MILONE, Michael, C. , MURPHY, Leon , RICHARDSON, Celeste , SINGH, Reshma , SONG, Huijuan , WU, Qilong , ZHANG, Jiquan
- 申请人地址： Lichtstrasse 35 CH-4056 Basel CH
- 专利权人： NOVARTIS AG,THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA,BROGDON, Jennifer,EBERSBACH, Hilmar,GILL, Saar,GLASS, David,HUBER, Thomas,JASCUR, Julia,KENDERIAN, Saad,MANNICK, Joan,MILONE, Michael, C.,MURPHY, Leon,RICHARDSON, Celeste,SINGH, Reshma,SONG, Huijuan,WU, Qilong,ZHANG, Jiquan
- 当前专利权人： NOVARTIS AG,THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA,BROGDON, Jennifer,EBERSBACH, Hilmar,GILL, Saar,GLASS, David,HUBER, Thomas,JASCUR, Julia,KENDERIAN, Saad,MANNICK, Joan,MILONE, Michael, C.,MURPHY, Leon,RICHARDSON, Celeste,SINGH, Reshma,SONG, Huijuan,WU, Qilong,ZHANG, Jiquan
- 当前专利权人地址： Lichtstrasse 35 CH-4056 Basel CH
- 代理机构： COLLAZO, Diana, M.
- 优先权： CNPCT/CN2014/082589 20140721; CNPCT/CN2014/090504 20141106
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C07K16/30 ; C07K14/725 ; C07K14/705 ; A61K39/395 ; A61K31/436 ; A61K35/17 ; A61P35/02
摘要：
The disclosure provides compositions and methods for treating diseases associated with expression of CD33. The disclosure also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The disclosure also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD33 binding domain.
摘要（中）：
本公开提供了用于治疗与CD33表达相关的疾病的组合物和方法。 本公开还涉及对CD33特异性的嵌合抗原受体（CAR），编码它的载体和包含CD33 CAR的重组T细胞。 本公开还包括施用表达包含CD33结合结构域的CAR的遗传修饰的T细胞的方法。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K16/00 | 免疫球蛋白，例如，单克隆或多克隆抗体 |
| --------C07K16/18 | .来自动物或人的抵抗物质 |
| ----------C07K16/28 | ..抗受体，细胞表面抗原或细胞表面决定因子 |