基本信息:
- 专利标题: FLUOROGEN ACTIVATING AND SHIFTING TAG (FAST)
- 专利标题(中):荧光激活和移位标记(快速)
- 申请号:PCT/EP2015065267 申请日:2015-07-03
- 公开(公告)号:WO2016001437A3 公开(公告)日:2016-02-25
- 发明人: GAUTIER ARNAUD , JULLIEN LUDOVIC
- 申请人: PARIS SCIENCES ET LETTRES QUARTIER LATIN , CENTRE NAT RECH SCIENT , UNIVERSITÉ PIERRE ET MARIE CURIE PARIS 6 UPMC
- 专利权人: PARIS SCIENCES ET LETTRES QUARTIER LATIN,CENTRE NAT RECH SCIENT,UNIVERSITÉ PIERRE ET MARIE CURIE PARIS 6 UPMC
- 当前专利权人: PARIS SCIENCES ET LETTRES QUARTIER LATIN,CENTRE NAT RECH SCIENT,UNIVERSITÉ PIERRE ET MARIE CURIE PARIS 6 UPMC
- 优先权: EP14175837 2014-07-04
- 主分类号: C07K14/195
- IPC分类号: C07K14/195 ; C07D277/26
摘要:
The present invention relates to a functional derivative of a Photoactive Yellow Protein (PYP), or a functional fragment thereof, for fluorescently labelling particles, e.g. proteins, or surfaces, which is capable of binding reversibly a fluorogenic chromophore of formula (I), and which is capable of enhancing the brightness of the said fluorogenic chromophore upon complexation thereto; and of inducing the spectral shift of the said fluorogenic chromophore through the ionization of an auxochromic group thereof.
摘要(中):
本发明涉及用于荧光标记颗粒的光敏黄蛋白(PYP)或其功能性片段的功能性衍生物, 蛋白质或表面,其能够可逆地结合式(I)的荧光发色团,并且能够在与其络合时增强所述荧光发色团的亮度; 并通过其辅助色素基团的电离诱导所述荧光发色团的光谱移位。
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07K | 肽 |
------C07K14/00 | 具有多于20个氨基酸的肽;促胃液素;生长激素释放抑制因子;促黑激素;其衍生物 |
--------C07K14/195 | .来自细菌 |