基本信息:
- 专利标题： FACTOR XIa INHIBITORS
- 专利标题（中）：因子XIA抑制剂
- 申请号：PCT/US2015/026774 申请日：2015-04-21
- 公开(公告)号：WO2015164308A1 公开(公告)日：2015-10-29
- 发明人： LIM, Yeon-Hee , GUO, Zhuyan , ALI, Amjad , EDMONDSON, Scott, D. , LIU, Weiguo , GALLO-ETIENNE, Gioconda, V. , WU, Heping , GAO, Ying-Duo , STAMFORD, Andrew, M. , YU, Younong , KEVIN, Nancy, J. , ANAND, Rajan , SHA, Deyou , NEELAMKAVIL, Santhosh, F. , HUSSAIN, Zahid , KUMAR, Puneet , MONINGKA, Remond , DUFFY, Joseph, L. , XU, Jiayi , JIANG, Yu , SONE, Hiroki , CHAKRABARTI, Anjan
- 申请人： MERCK SHARP & DOHME CORP. , LIM, Yeon-Hee , GUO, Zhuyan , ALI, Amjad , EDMONDSON, Scott, D. , LIU, Weiguo , GALLO-ETIENNE, Gioconda, V. , WU, Heping , GAO, Ying-Duo , STAMFORD, Andrew, M. , YU, Younong , KEVIN, Nancy, J. , ANAND, Rajan , SHA, Deyou , NEELAMKAVIL, Santhosh, F. , HUSSAIN, Zahid , KUMAR, Puneet , MONINGKA, Remond , DUFFY, Joseph, L. , XU, Jiayi , JIANG, Yu , SONE, Hiroki , CHAKRABARTI, Anjan
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 专利权人： MERCK SHARP & DOHME CORP.,LIM, Yeon-Hee,GUO, Zhuyan,ALI, Amjad,EDMONDSON, Scott, D.,LIU, Weiguo,GALLO-ETIENNE, Gioconda, V.,WU, Heping,GAO, Ying-Duo,STAMFORD, Andrew, M.,YU, Younong,KEVIN, Nancy, J.,ANAND, Rajan,SHA, Deyou,NEELAMKAVIL, Santhosh, F.,HUSSAIN, Zahid,KUMAR, Puneet,MONINGKA, Remond,DUFFY, Joseph, L.,XU, Jiayi,JIANG, Yu,SONE, Hiroki,CHAKRABARTI, Anjan
- 当前专利权人： MERCK SHARP & DOHME CORP.,LIM, Yeon-Hee,GUO, Zhuyan,ALI, Amjad,EDMONDSON, Scott, D.,LIU, Weiguo,GALLO-ETIENNE, Gioconda, V.,WU, Heping,GAO, Ying-Duo,STAMFORD, Andrew, M.,YU, Younong,KEVIN, Nancy, J.,ANAND, Rajan,SHA, Deyou,NEELAMKAVIL, Santhosh, F.,HUSSAIN, Zahid,KUMAR, Puneet,MONINGKA, Remond,DUFFY, Joseph, L.,XU, Jiayi,JIANG, Yu,SONE, Hiroki,CHAKRABARTI, Anjan
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 代理机构： FITCH, Catherine D.
- 优先权： US61/982,420 20140422
- 主分类号： C07D471/10
- IPC分类号： C07D471/10 ; A61K31/438 ; C07D498/20
摘要：
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
摘要（中）：
本发明提供式（I）的化合物和包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维变化的方法。 该化合物是选择性因子XIa抑制剂或因子XIa和血浆激肽释放酶的双重抑制剂。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D471/00 | 在稠环系中含有氮原子作为仅有的杂环原子、其中至少1个环是含有1个氮原子的六元环的杂环化合物，C07D451/00至C07D463/00不包括的 |
| --------C07D471/02 | .在稠环系中含两个杂环 |
| ----------C07D471/10 | ..螺稠合系 |