基本信息:
- 专利标题： ENOLASE 1 (ENO1) COMPOSITIONS AND USES THEREOF
- 申请号：PCT/US2015/011275 申请日：2015-01-13
- 公开(公告)号：WO2015106295A3 公开(公告)日：2015-07-16
- 发明人： NARAIN, Niven, Rajin , SARANGARAJAN, Rangaprasad , VISHNUDAS, Vivek, K. , GESTA, Stephane , JING, Enxuan
- 申请人： BERG LLC , NARAIN, Niven, Rajin , SARANGARAJAN, Rangaprasad , VISHNUDAS, Vivek, K. , GESTA, Stephane , JING, Enxuan
- 申请人地址： 1845 Elm Hill Pike Nashville, TN 37210 US
- 专利权人： BERG LLC,NARAIN, Niven, Rajin,SARANGARAJAN, Rangaprasad,VISHNUDAS, Vivek, K.,GESTA, Stephane,JING, Enxuan
- 当前专利权人： BERG LLC,NARAIN, Niven, Rajin,SARANGARAJAN, Rangaprasad,VISHNUDAS, Vivek, K.,GESTA, Stephane,JING, Enxuan
- 当前专利权人地址： 1845 Elm Hill Pike Nashville, TN 37210 US
- 代理机构： MELLO, Jill Ann et al.
- 优先权： US62/100,881 20150107; US62/009,783 20140609; US61/926,913 20140113
- 主分类号： A61P3/08
- IPC分类号： A61P3/08 ; A61K38/28 ; A61K38/46 ; C07K1/00 ; C12N15/00
摘要：
The invention provides compositions comprising Eno1 for delivery to a muscle. Further, the invention provides a method for normalizing blood glucose in a subject with elevated blood glucose, comprising administering to the subject enolase 1 (Eno1), thereby normalizing blood glucose in the subject. The invention also provides methods of treating one or more conditions including impaired glucose tolerance, insulin resistance, pre-diabetes, and diabetes, especially type 2 diabetes in a subject, comprising administering to the subject enolase 1 (Eno1), thereby treating the condition in the subject. In certain methods of the invention, the Eno1 is delivered to muscle.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61P | 化合物或药物制剂的治疗活性 |
| ------A61P3/00 | 治疗代谢疾病的药物 |
| --------A61P3/08 | .用于葡萄糖体内平衡的药物 |