基本信息:
- 专利标题: FLUORESCENT RED EMITTING FUNCTIONALIZABLE PH PROBES
- 专利标题(中):荧光红发射功能PH探针
- 申请号:PCT/EP2014/079271 申请日:2014-12-23
- 公开(公告)号:WO2015097262A1 公开(公告)日:2015-07-02
- 发明人: MALLET, Jean-Maurice , COLLOT, Mayeul
- 申请人: PARIS SCIENCES ET LETTRES - QUARTIER LATIN
- 申请人地址: Villa Pasteur 62 bis rue Gay-Lussac F-75005 Paris FR
- 专利权人: PARIS SCIENCES ET LETTRES - QUARTIER LATIN
- 当前专利权人: PARIS SCIENCES ET LETTRES - QUARTIER LATIN
- 当前专利权人地址: Villa Pasteur 62 bis rue Gay-Lussac F-75005 Paris FR
- 代理机构: ICOSA
- 优先权: EP13199575.5 20131224
- 主分类号: C07D491/00
- IPC分类号: C07D491/00 ; C09B56/00 ; C09B62/00
摘要:
The present invention relates to pH probes of formula I: wherein: W represents O, NH, N(alkyl), Si(alkyl) 2 , CH 2 , CH(alkyl), C(alkyl) 2 ; preferably W represents O; X 1 and X 1' represent both H, both Me or both -CH 2 -S0 3 H; X 2 and X 2' represent both H or both Me; X 3 and X 3' represent both H or both Me; X 4 and X 4' represent both H or both Me; X 5 and X 5' represent both H or both Me; X 6 and X 6' represent both H or both Me; Z 1 , Z 2 and Z 3 , represent each independently H, electron withdrawing group or electron donating group, L represents a single bound or a linker, Y represents a reactive group, or a bioactive group. The invention also relates to a process for manufacturing said compounds. The invention further relates to the use of the compounds of the invention as pH probes.
摘要(中):
本发明涉及式I的pH探针:其中:W代表O,NH,N(烷基),Si(烷基)2,CH2,CH(烷基),C(烷基) 优选W表示O; X1和X1'均表示H,Me或Me均为-CH2-SO3H; X2和X2'代表H或两者Me; X3和X 3'表示H或两者Me; X4和X4'代表H或两者Me; X5和X5'表示H或两者Me; X6和X6'均表示H或两者Me; Z1,Z2和Z3各自独立地表示H,吸电子基团或给电子基团,L表示单键或接头,Y表示反应性基团或生物活性基团。 本发明还涉及制备所述化合物的方法。 本发明还涉及本发明化合物作为pH探针的用途。