基本信息:
- 专利标题: IDENTIFICATION OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA)
- 专利标题(中):甲基西林耐药斑马鱼(MRSA)鉴定
- 申请号:PCT/EP2014/078470 申请日:2014-12-18
- 公开(公告)号:WO2015097061A1 公开(公告)日:2015-07-02
- 发明人: BIERBAUM, Gabriele , SZEKAT, Christiane , ALSABTI, Nahed , JOSTEN, Michaele , REIF, Marion
- 申请人: BRUKER DALTONIK GMBH
- 申请人地址: Fahrenheitstrasse 4 28359 Bremen DE
- 专利权人: BRUKER DALTONIK GMBH
- 当前专利权人: BRUKER DALTONIK GMBH
- 当前专利权人地址: Fahrenheitstrasse 4 28359 Bremen DE
- 代理机构: KOHLER SCHMID MÖBUS PATENTANWÄLTE et al.
- 优先权: US61/920,054 20131223
- 主分类号: G01N33/68
- IPC分类号: G01N33/68
摘要:
The invention provides a method for identifying methicillin resistant Staphylococcus aureus (MRSA) in a bacterial sample comprising the steps: classifying bacteria in the sample as Staphylococcus aureus (SA) and determining the presence or absence of the phenol soluble modulin peptide or a variant thereof wherein the presence of the PSM-mec peptide or variant thereof indicates methicillin resistant Staphylococcus aureus. The variant is preferably the formylated version of the PSM-mec peptide having a mass to charge ratio of 2415 in a singly protonated state.
摘要(中):
本发明提供了一种在细菌样品中鉴定耐甲氧西林金黄色葡萄球菌(MRSA)的方法,包括以下步骤:将样品中的细菌分类为金黄色葡萄球菌(SA),并测定苯酚可溶性调节素肽或其变体的存在或不存在,其中 PSM-mec肽或其变体的存在表示耐甲氧西林金黄色葡萄球菌。 该变体优选是在单质子化状态下质量与电荷比为2415的PSM-mec肽的甲酰化形式。