发明申请
WO2015069872A2 PERSONAL GLUCOSE METERS FOR DETECTION AND QUANTIFICATION OF ENZYMES AND METABOLITES BASED ON COENZYME DETECTION
审中-公开
基本信息:
- 专利标题： PERSONAL GLUCOSE METERS FOR DETECTION AND QUANTIFICATION OF ENZYMES AND METABOLITES BASED ON COENZYME DETECTION
- 专利标题（中）：基于辅酶检测的人体葡萄糖检测及定量酶和代谢物
- 申请号：PCT/US2014/064314 申请日：2014-11-06
- 公开(公告)号：WO2015069872A2 公开(公告)日：2015-05-14
- 发明人： LU, Yi , XIANG, Yu , ZHANG, JingJing
- 申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , LU, Yi , XIANG, Yu , ZHANG, JingJing
- 申请人地址： 352 Henry Administration Building 506 South Wright Street Urbana, IL 61801 US
- 专利权人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS,LU, Yi,XIANG, Yu,ZHANG, JingJing
- 当前专利权人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS,LU, Yi,XIANG, Yu,ZHANG, JingJing
- 当前专利权人地址： 352 Henry Administration Building 506 South Wright Street Urbana, IL 61801 US
- 代理机构： RYBAK, Sheree, Lynn
- 优先权： US61/901,688 20131108
- 主分类号： F16L55/115
- IPC分类号： F16L55/115
摘要：
A general methodology for highly sensitive and selective sensors and devices that can achieve portable, low-cost and quantitative detection of target enzymes and metabolites using a personal glucose meter (PGM) is disclosed. The method and sensors take advantage of the ability of PGMs to detect enzyme cofactors or coenzymes, such as nicotinamide adenine dinucleotide (NADH) or nicotinamide adenine dinucleotide phosphate (NADPH). Based on this observation, enzymes and metabolites involved in enzymatic reactions that consume or generate a coenzyme such as NADH or NADPH can be detected using PGMs, for example by measuring increases or decreases in NADH or NADPH levels. Methods of using such sensors and fluidic devices for detecting target enzymes and metabolites, for example to diagnose disease, are also provided.
摘要（中）：
公开了用于使用个人血糖仪（PGM）可实现便携式，低成本和定量检测靶酶和代谢物的高灵敏度和选择性传感器和装置的一般方法。 该方法和传感器利用PGM检测酶辅因子或辅酶（如烟酰胺腺嘌呤二核苷酸（NADH）或烟酰胺腺嘌呤二核苷酸磷酸（NADPH））的能力。 基于这一观察，参与酶消化或产生辅酶的酶和代谢物如NADH或NADPH可以使用PGM检测，例如通过测量NADH或NADPH水平的增加或减少。 还提供了使用这种传感器和流体装置来检测目标酶和代谢物以例如诊断疾病的方法。
IPC结构图谱:
| F | 机械工程；照明；加热；武器；爆破 |
| --F16 | 工程元件或部件；为产生和保持机器或设备的有效运行的一般措施；一般绝热 |
| ----F16L | 管接头 |
| ------F16L55/00 | 管中阀门的配置 |
| --------F16L55/10 | .用于停止流入或流出管子或软管的装置 |
| ----------F16L55/115 | ..帽盖 |