基本信息:
- 专利标题: STEM CELL MICROPARTICLES AND MIRNA
- 专利标题(中):干细胞微生物和米拉
- 申请号:PCT/GB2014/053044 申请日:2014-10-09
- 公开(公告)号:WO2015052526A1 公开(公告)日:2015-04-16
- 发明人: HICKS, Caroline , SINDEN, John , STEVANATO, Lara , CORTELING, Randolph
- 申请人: RENEURON LIMITED
- 申请人地址: 10 Nugent Road Surrey Research Park Guildford Surrey GU2 7AF GB
- 专利权人: RENEURON LIMITED
- 当前专利权人: RENEURON LIMITED
- 当前专利权人地址: 10 Nugent Road Surrey Research Park Guildford Surrey GU2 7AF GB
- 代理机构: GOODFELLOW, Hugh Robin et al.
- 优先权: GB1317887.6 20131009; GBPCT/GB2014/052509 20140814
- 主分类号: C12N5/0797
- IPC分类号: C12N5/0797 ; A61K35/30 ; A61P35/00
摘要:
This invention relates to stem cell microparticles and miRNA isolated from these microparticles, their use and production thereof, in particular neural stem cell microparticles and their use in therapy of cancer, typically a nestin-positive cancer. The cancer may be glioma, melanoma, breast cancer, pancreatic cancer or prostate cancer. The stem cell microparticle is typically an exosome or microvesicle and may be derived from a neural stem cell line. The neural stem cell line may be a conditionally-immortalised stem cell line such as CTX0E03 (deposited at the ECACC with Accession No. 04091601).
摘要(中):
本发明涉及从这些微粒分离的干细胞微粒和miRNA,其使用和生产,特别是神经干细胞微粒及其在癌症治疗中的用途,通常是巢蛋白阳性癌症。 癌症可能是胶质瘤,黑素瘤,乳腺癌,胰腺癌或前列腺癌。 干细胞微粒通常是外来体或微泡,并且可以衍生自神经干细胞系。 神经干细胞系可以是有条件永生化的干细胞系,例如CTX0E03(在ECACC上保藏,登录号为04091601)。