基本信息:
- 专利标题： ACELLULAR SOFT TISSUE-DERIVED MATRICES AND METHODS FOR PREPARING SAME
- 专利标题（中）：细胞软骨组织衍生的基质及其制备方法
- 申请号：PCT/US2014/048797 申请日：2014-07-30
- 公开(公告)号：WO2015017500A1 公开(公告)日：2015-02-05
- 发明人： HUANG, Yen-Chen , IVERY, Asia , CHOI, Bryan , SCHILLING, Benjamin , NGO, Manh-Dan
- 申请人： MUSCULOSKELETAL TRANSPLANT FOUNDATION , HUANG, Yen-Chen , IVERY, Asia , CHOI, Bryan , SCHILLING, Benjamin , NGO, Manh-Dan
- 申请人地址： 125 May Street, Suite 300, Edison Corporate Center Edison, NJ 08837 US
- 专利权人： MUSCULOSKELETAL TRANSPLANT FOUNDATION,HUANG, Yen-Chen,IVERY, Asia,CHOI, Bryan,SCHILLING, Benjamin,NGO, Manh-Dan
- 当前专利权人： MUSCULOSKELETAL TRANSPLANT FOUNDATION,HUANG, Yen-Chen,IVERY, Asia,CHOI, Bryan,SCHILLING, Benjamin,NGO, Manh-Dan
- 当前专利权人地址： 125 May Street, Suite 300, Edison Corporate Center Edison, NJ 08837 US
- 代理机构： SELITTO, Ralph, W., Jr.
- 优先权： US61/860,043 20130730
- 主分类号： A61L27/36
- IPC分类号： A61L27/36
摘要：
An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.
摘要（中）：
无细胞软组织衍生基质包括已经脱脂和脱细胞的胶原组织。 脂肪组织是适合制造无细胞软组织衍生基质的软组织之一。 可以将外源性组织细胞和其他生物活性因子加入到无细胞基质中。 无细胞基质可以作为颗粒，浆液，糊剂，凝胶或其它形式提供。 无细胞基质可以提供为已经从三维组织的颗粒重构的三维支架。 三维支架可以具有解剖特征的形状并且用作用于组织修复或替换的模板。 制备无细胞软组织衍生基质的方法包括通过溶液萃取和软组织的化学脱细胞化从软组织中除去脂质的步骤。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61L | 材料或物体消毒的一般方法或装置；空气的灭菌、消毒或除臭；绷带、敷料、吸收垫或外科用品的化学方面；绷带、敷料、吸收垫或外科用品的材料 |
| ------A61L27/00 | 假体材料或假体被覆材料 |
| --------A61L27/36 | .含有未确定结构的组分或其反应产物 |