基本信息:
- 专利标题： ANTI-COMPLEMENT FACTOR C1S ANTIBODIES AND USES THEREOF
- 专利标题（中）：抗补体因子C1S抗体及其用途
- 申请号：PCT/US2014038239 申请日：2014-05-15
- 公开(公告)号：WO2014186599A3 公开(公告)日：2015-06-04
- 发明人： ROSENTHAL ARNON , LEVITEN MICHAEL
- 申请人： ANNEXON INC
- 专利权人： ANNEXON INC
- 当前专利权人： ANNEXON INC
- 优先权： US201361823876 2013-05-15
- 主分类号： C07K16/40
- IPC分类号： C07K16/40
摘要：
The present invention relates generally to the generation and characterization of neutralizing anti-C1s monoclonal antibodies. The invention further relates to the use of such anti-C1s antibodies in the detection of complement factors of the classical complement activation pathway, such as C1s. Additionally, the antibodies of this disclosure are useful for the diagnosis and treatment of disorders associated with an increased activation of the classical complement pathway, in particular autoimmune disorders and neurodegenerative diseases, including neurodegenerative diseases with synapse loss, such as Alzheimer's Disease. Methods of treatment of autoimmune and neurodegenerative diseases are also provided.
摘要（中）：
本发明一般涉及中和抗C1s单克隆抗体的产生和表征。 本发明还涉及这种抗C1s抗体在检测经典补体活化途径的补体因子例如C1s中的用途。 此外，本公开的抗体可用于诊断和治疗与经典补体途径的增加，特别是自身免疫性疾病和神经变性疾病（包括具有突触缺失的神经退行性疾病如阿尔茨海默氏病）的增加相关的病症。 还提供了治疗自身免疫性和神经变性疾病的方法。