发明申请
WO2014144858A1 THERAPEUTIC METHODS FOR TREATING SOLID TUMORS AND RELATED DIAGNOSTIC METHODS
审中-公开
基本信息:
- 专利标题： THERAPEUTIC METHODS FOR TREATING SOLID TUMORS AND RELATED DIAGNOSTIC METHODS
- 专利标题（中）：治疗固体肿瘤的治疗方法及相关诊断方法
- 申请号：PCT/US2014/029445 申请日：2014-03-14
- 公开(公告)号：WO2014144858A1 公开(公告)日：2014-09-18
- 发明人： BANGI, Erdem , CAGAN, Ross
- 申请人： ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI , BANGI, Erdem , CAGAN, Ross
- 申请人地址： One Gustave L. Levy Place New York, NY 10029 US
- 专利权人： ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI,BANGI, Erdem,CAGAN, Ross
- 当前专利权人： ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI,BANGI, Erdem,CAGAN, Ross
- 当前专利权人地址： One Gustave L. Levy Place New York, NY 10029 US
- 代理机构： WHITE, John, P.
- 优先权： US61/799,595 20130315; US61/895,265 20131024
- 主分类号： A61K31/711
- IPC分类号： A61K31/711
摘要：
The present invention provides a method for treating a subject afflicted with a cancer which comprises administering to the subject (i) a proteasome antagonist and (ii) a PI3K signal transduction pathway antagonist, each of (i) and (ii) in an amount such that when both (i) and (ii) are administered, the administration is effective to treat the subject. The present invention also provides a method for treating a subject afflicted with a cancer which comprises administering to the subject (i) a proteasome antagonist, and (ii) an oligonucleotide which decreases the amount of PI3K,mTor, TORC1, TORC2, AKT, or JNK produced by cells of the cancer. The present invention provides processes for identifying whether a compound is an epithelial cancer drug candidate. The present invention also provides a method for identifying a cancer patient who will likely benefit from treatment with a PI3K signal transduction pathway antagonist.
摘要（中）：
本发明提供了治疗患有癌症的受试者的方法，其包括向受试者（i）施用蛋白酶体拮抗剂和（ii）PI3K信号转导途径拮抗剂，每种（i）和（ii） 当施用（i）和（ii）时，给药可有效治疗受试者。 本发明还提供了治疗患有癌症的受试者的方法，其包括给予受试者（i）蛋白酶体拮抗剂，和（ii）降低PI3K，mTor，TORC1，TORC2，AKT或 JNK由癌细胞产生。 本发明提供鉴定化合物是否是上皮癌候选药物的方法。 本发明还提供了鉴定可能受益于PI3K信号转导途径拮抗剂治疗的癌症患者的方法。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/70 | .碳水化合物；糖；其衍生物 |
| ----------A61K31/7088 | ..含有3个或更多个核苷或核苷酸的化合物 |
| ------------A61K31/711 | ...天然脱氧核糖核酸，即仅含有与腺嘌呤、鸟嘌呤、胞嘧啶、尿嘧啶或胸腺嘧啶相连的2′脱氧核糖并含有3′,5′磷酸二酯键的 |