发明申请
WO2014123793A1 TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HEPATITIS C
审中-公开
基本信息:
- 专利标题： TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HEPATITIS C
- 专利标题（中）：四环杂环化合物及其用于治疗乙型肝炎的方法
- 申请号：PCT/US2014/014361 申请日：2014-02-03
- 公开(公告)号：WO2014123793A1 公开(公告)日：2014-08-14
- 发明人： DAI, Xing , LIU, Hong , PALANI, Anandan , HE, Shuwen , BROCKUNIER, Linda, L. , NARGUND, Ravi , MARCANTONIO, Karen , ZORN, Nicolas , XIAO, Dong , PENG, Xuanjia , LI, Peng , GUO, Tao
- 申请人： MERCK SHARP & DOHME CORP. , DAI, Xing , LIU, Hong , PALANI, Anandan , HE, Shuwen , BROCKUNIER, Linda, L. , NARGUND, Ravi , MARCANTONIO, Karen , ZORN, Nicolas , XIAO, Dong , PENG, Xuanjia , LI, Peng , GUO, Tao
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 专利权人： MERCK SHARP & DOHME CORP.,DAI, Xing,LIU, Hong,PALANI, Anandan,HE, Shuwen,BROCKUNIER, Linda, L.,NARGUND, Ravi,MARCANTONIO, Karen,ZORN, Nicolas,XIAO, Dong,PENG, Xuanjia,LI, Peng,GUO, Tao
- 当前专利权人： MERCK SHARP & DOHME CORP.,DAI, Xing,LIU, Hong,PALANI, Anandan,HE, Shuwen,BROCKUNIER, Linda, L.,NARGUND, Ravi,MARCANTONIO, Karen,ZORN, Nicolas,XIAO, Dong,PENG, Xuanjia,LI, Peng,GUO, Tao
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 代理机构： MERCK SHARP & DOHME CORP.
- 优先权： CNPCT/CN2013/000128 20130207
- 主分类号： A01N43/00
- IPC分类号： A01N43/00 ; A61K31/397
摘要：
The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要（中）：
本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的用途的式I化合物和 抑制基于细胞的系统中的HCV病毒复制和/或病毒生产。