基本信息:
- 专利标题： INDAZOLE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS
- 专利标题（中）：作为醛固酮合成酶抑制剂的INDAZOLE化合物
- 申请号：PCT/US2013/075528 申请日：2013-12-17
- 公开(公告)号：WO2014099833A1 公开(公告)日：2014-06-26
- 发明人： HOYT, Scott, B. , TAYLOR, Jerry Andrew , LONDON, Clare , XIONG, Yusheng , COOKE, Andrew John
- 申请人： MERCK SHARP & DOHME CORP. , HOYT, Scott, B. , TAYLOR, Jerry Andrew , LONDON, Clare , XIONG, Yusheng , COOKE, Andrew John
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 专利权人： MERCK SHARP & DOHME CORP.,HOYT, Scott, B.,TAYLOR, Jerry Andrew,LONDON, Clare,XIONG, Yusheng,COOKE, Andrew John
- 当前专利权人： MERCK SHARP & DOHME CORP.,HOYT, Scott, B.,TAYLOR, Jerry Andrew,LONDON, Clare,XIONG, Yusheng,COOKE, Andrew John
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 代理机构： MERCK SHARP & DOHME CORP.
- 优先权： US61/739,807 20121220
- 主分类号： A01N43/46
- IPC分类号： A01N43/46 ; A61K31/415 ; C07D401/04
摘要：
This invention relates to indazole compounds of the structural formula: (structure represented) or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment or amelioration of conditions that could be treated by inhibiting aldosterone synthase.
摘要（中）：
本发明涉及结构式为（结构式）的吲唑化合物或其药学上可接受的盐，其中该变量在本文中定义。 本发明化合物选择性地抑制醛固酮合酶。 本发明还提供包含式I化合物或其盐的药物组合物，以及可能用于治疗或改善可通过抑制醛固酮合酶治疗的病症的方法。